Cancer risk and tumour spectrum in 172 patients with a germline SUFU pathogenic variation: a collaborative study of the SIOPE Host Genome Working Group

Conclusion
Germline SUFU PV carriers have a life-long increased risk of tumours with a spectrum dominated by MB before the age of 5, gonadal tumours during adolescence and BCC and meningioma in adulthood, justifying fine-tuned surveillance programmes.

Source: Journal of Medical Genetics - October 21, 2022 Category: Genetics & Stem Cells Authors: Guerrini-Rousseau, L., Masliah-Planchon, J., Waszak, S. M., Alhopuro, P., Benusiglio, P. R., Bourdeaut, F., Brecht, I. B., Del Baldo, G., Dhanda, S. K., Garre, M. L., Gidding, C. E. M., Hirsch, S., Hoarau, P., Jorgensen, M., Kratz, C., Lafay-Cousin, L., M Tags: Open access Cancer genetics Source Type: research