5-HT < sub > 3 < /sub > receptors modulate changes in voiding pattern and bladder contractility in water avoidance stress-induced bladder overactivity in male mice

CONCLUSIONS: Water avoidance stress-induced mice exhibited changes in voiding pattern, which was reversed by oral administration with a 5-HT3 receptor antagonist (ondansetron). Enhanced contractile response to cholinergic stimulation in the urinary bladder of the psychological stress-induced bladder overactivity was mediated through 5-HT3 receptors.PMID:36215921 | DOI:10.1016/j.autneu.2022.103040

Source: Autonomic Neuroscience - October 10, 2022 Category: Neuroscience Authors: Sarunnuch Sattayachiti Affan Waemong Dania Cheaha Nipaporn Konthapakdee Source Type: research