Comparison of laboratory methods for the detection of neoplastic plasma cells in plasma cell dyscrasias

Conclusions While CD138+sorted FISH is primarily used for prognostication, it may be employed as a single test for detection and monitoring clonality in certain scenarios. Further studies are needed to monitor the outcomes of patients with positive FISH and negative IHC and MFC. Additionally, there was high agreement between IHC and MFC, suggesting that performing both tests may not be necessary.
Source: Journal of Clinical Pathology - Category: Pathology Authors: Tags: Best practice Source Type: research