Impact of the COVID-19 Pandemic on the Implementation of Mobile Health to Improve the Uptake of Hydroxyurea in Patients With Sickle Cell Disease: Mixed Methods Study

CONCLUSIONS: We found significant impacts of the early clinic lockdowns, which reduced implementation of the mHealth intervention and led to reduced patient adherence to hydroxyurea. However, disruptions were lower among participants who experienced shorter clinic lockdowns and were associated with higher hydroxyurea adherence. Investigation of added strategies to mitigate the effects of care interruptions during major emergencies (eg, patient coaching and health navigation) may "insulate" the implementation of interventions to increase medication adherence.TRIAL REGISTRATION: ClinicalTrials.gov NCT04080167; https://clinicaltrials.gov/ct2/show/NCT04080167.INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.2196/16319.PMID:36240004 | DOI:10.2196/41415

Source: Cell Research - October 14, 2022 Category: Cytology Authors: Sherif M Badawy Lisa DiMartino Donald Brambilla Lisa Klesges Ana Baumann Ebony Burns Terri DeMartino Sara Jacobs Hamda Khan Chinonyelum Nwosu Nirmish Shah Jane S Hankins Sickle Cell Disease Implementation Consortium Source Type: research