Sex-dependent neuro-deconvolution analysis of Alzheimer's disease brain transcriptomes according to CHI3L1 expression levels
Glial activation and related neuroinflammatory processes play a key role in the aging and progression of Alzheimer's disease (AD). CHI3L1/ YKL40 is a widely investigated chitinase in neurodegenerative diseases and recent studies have shown its involvement in aging and AD. Nevertheless, the biological function of CHI3L1 in AD is still unknown. Here, we collected microarray datasets from the National Center for Biotechnology Information (NCBI) brain samples of not demented healthy controls (NDHC) who died from causes not attributable to neurodegenerative disorders (n = 460), and of deceased patients suffering from Alzheimer's disease (AD) (n = 697).
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Cristina Sanfilippo, Paola Castrogiovanni, Rosa Imbesi, Giuseppe Musumeci, Michele Vecchio, Giovanni Li Volti, Daniele Tibullo, Giuseppe Broggi, Rosario Caltabiano, Martina Ulivieri, Maria Kazakova, Rosalba Parenti, Nunzio Vicario, Francesco Fazio, Michel Source Type: research