Enrichment of serum IgG4 in MuSK myasthenia gravis patients

Muscle-specific kinase (MuSK) myasthenia gravis (MG) is a neuromuscular autoimmune disease belonging to a growing group of IgG4 autoimmune diseases (IgG4-AIDs), in which the majority of pathogenic autoantibodies are of the IgG4 subclass. The more prevalent form of MG with acetylcholine receptor (AChR) antibodies is caused by IgG1 –3 autoantibodies. A dominant role for IgG4 in autoimmune disease is intriguing due to its anti-inflammatory characteristics. It is unclear why MuSK autoantibodies are predominantly IgG4.

Source: Journal of Neuroimmunology - October 7, 2022 Category: Allergy & Immunology Authors: Dana L.E. Vergoossen, Annabel M. Ruiter, Kevin R. Keene, Erik H. Niks, Martijn R. Tannemaat, Ellen Strijbos, Alexander F. Lipka, Els C. Jol van der Zijde, Maarten J.D. van Tol, Jaap A. Bakker, Brigitte A. Wevers, Elisabet Westerberg, L úcia S. Borges, Ol Tags: Short Communication Source Type: research