Methylation Analyses Reveal Promoter Hypermethylation as a Rare Cause of “Second Hit” in Germline BRCA1-Associated Pancreatic Ductal Adenocarcinoma

ConclusionsIn patients withgBRCA1-P/LPV-PDAC, loss of heterozygosity is the main inactivating mechanism of the wild-typeBRCA1 allele in the tumor, and methylation of theBRCA1 promoter is a distinctly uncommon occurrence.
Source: Molecular Diagnosis and Therapy - Category: Molecular Biology Source Type: research