HFpEF etiology – Can focus on sex-specific mechanisms deliver insights for all?

In considering the heart failure with preserved ejection fraction (HFpEF) conundrum, the standard and disturbing preamble is almost ubiquitous: HFpEF has overtaken heart failure with reduced ejection fraction (HFrEF) as the major form of new failure diagnosis, incidence is escalating alarmingly, and there is no specific therapy for HFpEF. The historical perspective on the emergence of HFpEF has been elegantly chronicled [1]. It seems that achieving a definitive HFpEF diagnosis has always been problematic.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Tags: Letter to the editor Source Type: research