Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or K < sub > ATP < /sub > channels inhibitors

CONCLUSION: Lasmiditan and sumatriptan significantly increased post-stroke seizure thresholds in mice by suppressing inflammatory cytokines and neuronal apoptosis. Lasmiditan and sumatriptan seem to exert higher effects on seizure threshold with concurrent administration of the opioid receptors or KATP channels modulators.PMID:36155770 | DOI:10.1016/j.taap.2022.116254
Source: Toxicology and Applied Pharmacology - Category: Toxicology Authors: Source Type: research