APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer ’s disease pathology and brain diseases

ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for ...

Source: Molecular Neurodegeneration - September 24, 2022 Category: Neurology Authors: Rosal ía Fernández-Calle, Sabine C. Konings, Javier Frontiñán-Rubio, Juan García-Revilla, Lluís Camprubí-Ferrer, Martina Svensson, Isak Martinson, Antonio Boza-Serrano, José Luís Venero, Henrietta M. Nielsen, Gunnar K. Gouras and Tomas Deierborg Tags: Review Source Type: research