K < sub > V < /sub > 4 channels in isolectin B4 muscle dorsal root ganglion neurons of rats with experimental peripheral artery disease: Effects of bradykinin B1 and B2 receptors

In conclusion, our data suggest that limb ischemia and/or ischemia induced-BK inhibit activity of KV4 channels in a subpopulation of the thin fiber muscle afferent neurons depending on GDNF, which is likely a part of signaling pathways involved in the exaggerated blood pressure response during activation of muscle afferent nerves in PAD.PMID:36094447 | DOI:10.1152/ajpregu.00117.2022
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Source Type: research