Primary Biliary Cholangitis in Males

Primary biliary cholangitis (PBC) is an immune-mediated chronic liver disease characterized by progressive cholestasis, bile duct destruction, biliary fibrosis, and cirrhosis. Patients who respond to ursodeoxycholic acid have an expected survival similar to the general population. Although PBC primarily affects females, the prevalence in males is higher than was previously believed, with contemporary studies suggesting a female-to-male ratio of 4 –6:1. A diagnosis of PBC is often delayed among males because of the myth that PBC is rare in males.

Source: Clinics in Liver Disease - September 13, 2022 Category: Gastroenterology Authors: Mina Shaker, Natalie Mansour, Binu V. John Source Type: research