Dihydroartemisinin inhibited the Warburg effect through YAP1/SLC2A1 pathway in hepatocellular carcinoma

This study sought to determine the role of DHA in the SLC2A1 mediated Warburg effect in HCC. In this study, DHA inhibited the Warburg effect and SLC2A1 in HepG2215 cells and mice with liver tumors in situ. Meanwhile, DHA inhibited YAP1 expression by inhibiting YAP1 promoter binding protein GA binding protein transcription factor subunit beta 1 (GABPB1) and cAMP responsive element binding protein 1 (CREB1). Further,YAP1 knockdown/knockout reduced the Warburg effect and SLC2A1 expression byshYAP1-HepG2215 cells andYap1LKO mice with liver tumors. Taken together, our data indicated thatYAP1 knockdown/knockout reduced the SLC2A1 mediated Warburg effect byshYAP1-HepG2215 cells andYap1LKO mice with liver tumors induced by DEN/TCPOBOP. DHA, as a potential YAP1 inhibitor, suppressed the SLC2A1 mediated Warburg effect in HCC.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research