Oxytocin impacts top-down and bottom-up social perception in adolescents with ASD: a MEG study of neural connectivity

ConclusionThese results suggest that OT influenced social perception by modifying the communication between frontal and posterior regions, an attenuation that potentially impacts both social and non-social early perception. We also show that OT influences differ between top-down and bottom-up processes, depending on the social context. Overall, by showing that OT influences both social-related perception and overall attention during early processing stages, we add new information to the existing understanding of the impact of OT on neural processing in ASD. Furthermore, by highlighting the influence of OT on early perception, we provide new directions for treatments for difficulties in early attentional phases in this population.Trial registration Registered on October 27, 2021 —Retrospectively registered,https://clinicaltrials.gov/ct2/show/record/NCT05096676 (details on clinical registration can be found inwww.clinicalTrial.gov, unique identifier:NCT05096676).
Source: Molecular Autism - Category: Molecular Biology Source Type: research