The pathophysiology of major depressive disorder through the lens of systems biology: Network analysis of the psycho-immune-neuroendocrine physiome

The psycho-immune-neuroendocrine (PINE) network is a predominantly physiological (metabolomic) model constructed from the literature, inter-linking multiple biological processes associated with major depressive disorder (MDD), thereby integrating putative mechanistic pathways for MDD into a single network.

Source: Journal of Neuroimmunology - September 2, 2022 Category: Allergy & Immunology Authors: Nicolas J.C. Stapelberg, Tuan A. Bui, Verena Mansour, Susannah Johnson, Grace Branjerdporn, Sam Adhikary, Kevin Ashton, Nevin Taylor, John P. Headrick Tags: Review Article Source Type: research