Dysfunctional Dopaminergic Neurones in Mouse Models of Huntington's Disease: A Role for SK3 Channels.

CONCLUSIONS: Dopaminergic neuronal dysfunction is a key early event in HD disease progression. The initial increase in dopamine release appears to be related to a loss of SK3 channel function, a protein containing a polyglutamine tract. Implications for polyglutamine-mediated sequestration of SK3 channels, dopamine-associated DNA damage and CAG expansion are discussed in the context of HD. © 2015 S. Karger AG, Basel. PMID: 25871323 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/25871323?dopt=Abstract

Source: Neuro-Degenerative Diseases - April 9, 2015 Category: Neurology Authors: Dallérac GM, Levasseur G, Vatsavayai SC, Milnerwood AJ, Cummings DM, Kraev I, Huetz C, Evans KA, Walters SW, Rezaie P, Cho Y, Hirst MC, Murphy KP Tags: Neurodegener Dis Source Type: research