Salivary 17-hydroxyprogesterone levels in children with congenital adrenal hyperplasia – a retrospective longitudinal study considering auxological parameters

Conclusion. The measurement of s17-OHP is an important sub-aspect in the overall assessment of treatment response in CAH. It can provide an indication of over-/undertreatment and allows the assessment of day profiles especially in phases of changing (e.g. puberty) steroid requirements. We present here observational data from a larger cohort with longitudinal multiple measurements of s17-OHP. The values do not allow a significant differentiation between normal and abnormal growth or pubertal status. Thus, relying solely on s17-OHP is not advisable.
Source: Hormone Research in Paediatrics - Category: Endocrinology Source Type: research