Altered macronutrient composition and genetics influence the complex transcriptional network associated with adiposity in the Collaborative Cross

ConclusionsGenetic background affected hepatic gene expression in the CC overall, but diet macronutrient differences also altered expression of a specific subset of genes. Changes in macronutrient composition altered gene expression related to metabolic processes, while genetic background heavily influenced a broad range of cellular functions and processes irrespective of adiposity. Understanding the individual role of macronutrient composition, genetics, and their interaction is critical to developing therapeutic strategies and policy recommendations for precision nutrition.
Source: Genes and Nutrition - Category: Nutrition Source Type: research