Ceramide profiling of stratum corneum in Sj ögren–Larsson syndrome

Sj ögren–Larsson syndrome (SLS) is a neurocutaneous disorder whose causative gene is the fatty aldehyde dehydrogenase ALDH3A2 and of which ichthyosis is the major skin symptom. The stratum corneum contains a variety of ceramides, among which ω-O-acylceramides (acylceramides) and protein-bound ceram ides are essential for skin permeability barrier formation.

Source: Journal of Dermatological Science - August 8, 2022 Category: Dermatology Authors: Ayami Arai, Takuya Takeichi, Hiroyuki Wakamoto, Takayuki Sassa, Yasutoshi Ito, Yuya Murase, Tomoo Ogi, Masashi Akiyama, Akio Kihara Source Type: research