Paclitaxel exposure-toxicity analysis reveals a pharmacokinetic determinant for dose-limiting neutropenia in East-Asian solid tumor patients: results from two prospective, phase II studies

ConclusionPatients with PTX Tc  >  0.05 duration above 39 h experience more severe neutropenia than those under 39 h. Prospective studies are needed to verify this threshold.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research