The Everted Amygdala of Ray-Finned Fish: Zebrafish Makes a Case

The amygdala, a complex array of nuclei in the forebrain, controls emotions and emotion-related behaviors in vertebrates. Current research aims to understand the amygdala ’s evolution in ray-finned fish such as zebrafish because of the region’s relevance for social behavior and human psychiatric disorders. Clear-cut molecular definitions of the amygdala and its evolutionary-developmental relationship to the one of mammals are critical for zebrafish models of affe ctive disorders and autism. In this review, I argue that the prosomeric model and a focus on the olfactory system’s organization provide ideal tools for discovering deep ancestral relationships between the emotional systems of zebrafish and mammals. The review’s focus is on the “extended amygd ala,” which refers to subpallial amygdaloid territories including the central (autonomic) and the medial (olfactory) amygdala required for reproductive and social behaviors. Amphibians, sauropsids, and lungfish share many characteristics with the basic amygdala ground plan of mammals, as molecular and hodological studies have shown. Further exploration of the evolution of the amygdala in basally derived fish vertebrates requires researchers to test these “tetrapod-based” concepts. Historically, this has been a daunting task because the forebrains of basally derived fish vertebrates look very different from those of more familiar tetrapod ones. An extreme case are ray-finned fish (Actinopterygii) like zebrafish b...
Source: Brain, Behavior and Evolution - Category: Neurology Source Type: research