The change of serum and CSF BDNF level as a prognosis predictor in traumatic brain injury cases: A systematic review

CONCLUSION: Serum BDNF levels were found to be lower in the unfavorable group than in the favorable group. This is associated with an increase in autonomic function as well as a breakdown of the blood-brain barrier which causes a decrease in serum BDNF levels. Conversely, CSF BDNF levels were found to be higher in the unfavorable group than in the favorable group. This is associated with an increase in the breakdown of the blood-brain barrier which facilitates the transfer of serum BDNF to the brain, leading to an increase in CSF BDNF levels.PMID:35855138 | PMC:PMC9282766 | DOI:10.25259/SNI_1245_2021
Source: Surgical Neurology International - Category: Neurosurgery Authors: Source Type: research