Improved Ca2+ release synchrony following selective modification of Itof and phase 1 repolarization in normal and failing ventricular myocytes

Loss of ventricular action potential (AP) early phase 1 repolarization may contribute to the impaired Ca2+ release and increased risk of sudden cardiac death in heart failure. Therefore, restoring AP phase 1 by augmenting the fast transient outward K+ current (Itof) might be beneficial, but direct experimental evidence to support this proposition in failing cardiomyocytes is limited. Dynamic clamp was used to selectively modulate the contribution of Itof to the AP and Ca2+ transient in both normal (guinea pig and rabbit) and in failing rabbit cardiac myocytes.

Source: Journal of Molecular and Cellular Cardiology - July 28, 2022 Category: Cytology Authors: Ewan D. Fowler, Nan Wang, Melanie J. Hezzell, Guillaume Chanoit, Jules C. Hancox, Mark B. Cannell Source Type: research