PLC (Phospholipase C) β2 Promotes VEGF (Vascular Endothelial Growth Factor)-Induced Vascular Permeability

CONCLUSIONS: The results implicate PLCβ2 as a key positive regulator of VEGF-induced vascular permeability through regulation of both calcium flux and phosphatidylinositol 4,5-bisphosphate levels at the cellular level. Targeting of PLCβ2 in a therapeutic setting may provide a novel approach to regulating vascular permeability in patients.PMID:35861069 | DOI:10.1161/ATVBAHA.122.317645

Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 21, 2022 Category: Cardiology Authors: Kathryn N Phoenix Zhichao Yue Lixia Yue Chunxia G Cronin Bruce T Liang Luke H Hoeppner Kevin P Claffey Source Type: research