Characteristics of Heart Failure With Preserved Ejection Fraction Across the Range of Left Ventricular Ejection Fraction

CONCLUSIONS: Patients with HFpEF in whom LVEF ranged from 50% to 60% demonstrated reduced contractility, impaired ventriculo-arterial coupling, and higher extracellular volume fraction. In contrast, patients with HFpEF and a LVEF >60% demonstrated a hypercontractile state with excessive LV afterload and diminished preload reserve. A LVEF-based stratification of patients with HFpEF identified distinct morphologic and pathophysiologic subphenotypes.PMID:35862208 | DOI:10.1161/CIRCULATIONAHA.122.059280

Source: Circulation - July 21, 2022 Category: Cardiology Authors: Sebastian Rosch Karl-Patrik Kresoja Christian Besler Karl Fengler Anne Rebecca Sch öber Maximilian von Roeder Christian L ücke Matthias Gutberlet Karin Klingel Holger Thiele Karl-Philipp Rommel Philipp Lurz Source Type: research