Retrieving the deleterious mutations before extinction: genome-wide comparison of shared derived mutations in liver cancer and normal population

Conclusions Deleterious mutations are suppressed in functionally important genes as well as in normal populations. This work deepened our understanding on how natural selection act on deleterious mutations by analogising the cancer evolution to species evolution, which are essentially the same molecular process but at different time scales.
Source: Postgraduate Medical Journal - Category: General Medicine Authors: Tags: Original research Source Type: research