Recent advances in the development of transplanted colorectal cancer mouse models

Despite progress in prevention and treatment, colorectal cancer (CRC) remains the third most common malignancy worldwide and the second most common cause of cancer death in 2020. To evaluate various characteristics of human CRC, a variety of mouse models have been established. Transplant mouse models have distinct advantages in studying the clinical behaviour and therapeutic progress of CRC. Host, xenograft, and transplantation routes are the basis of transplant mouse models. As the effects of the tumour microenvironment and the systemic environment on cancer cells are gradually revealed, three key elements of transplanted CRC mouse models have been revolutionized.
Source: Translational Research - Category: Research Authors: Tags: Review Article Source Type: research