Correlation of Serum Estradiol with Bone Mineral Density and Bone Metabolism in Patients of Postmenopausal Type 2 Diabetes Mellitus Complicated with Osteoporosis
This study aims to demonstrate the correlation
between serum estradiol (E2) levels and osteoporosis, bone mineral density, and
bone metabolism indicators in postmenopausal women with T2DM complicated with
osteoporosis (T2DM-OP). 130 postmenopausal women with T2DM were divided into the
T2DM group (n=62) and the T2DM-OP group (n=68) according to bone
mineral density (BMD). In addition, 80 postmenopausal women with average blood
glucose and bone density were selected as the healthy control group. We compare
the serum levels of E2, bone metabolism indicators, and biochemistry indexes
among the three groups of participants. Compared with the healthy control and
T2DM groups, the BMD and serum level of E2 in T2DM-OP patients were
significantly decreased, while the serum levels of bone alkaline phosphatase,
type I procollagen amino-terminal propeptide, osteocalcin, and
β-collagen C-terminal collagen cross-links were significantly increased.
The serum levels of E2 in the postmenopausal T2DM-OP patients are positively
correlated with BMD and negatively correlated with bone resorption
indicators. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Yang, Fan Xu, Qiangwei Tags: Original Article: Endocrine Care Source Type: research
More News: Biochemistry | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Endocrinology | Estradiol | Hormones | Orthopaedics | Osteoporosis | Study | Women