Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood –brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis

ConclusionIn addition to transiently suppressing lymphocytes, CYM-5442 alleviated the neurological deficits, cerebral edema and protective BBB permeability in TBI mice by reducing the vesicle transcytosis of cerebrovascular endothelial cells.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research