Serum proprotein convertase subtilisin/kexin type 9 concentration is not increased by plant stanol ester consumption in normo- to moderately hypercholesterolemic non-obese subjects. The Blood Flow intervention study

Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates LDL cholesterol metabolism by targeting LDL receptors for degradation. Statins increase serum PCSK9 concentration limiting the potential of statins to reduce LDL cholesterol, whereas ezetimibe, inhibitor of cholesterol absorption, has ambiguous effects on circulating PCSK9 levels. Plant stanols also reduce cholesterol absorption, but their effect on serum PCSK9 concentration is not known. Therefore, we performed a controlled, randomized, double-blind study, in which 92 normo- to moderately hypercholesterolemic subjects (35 males and 57 females) consumed vegetable-oil spread 20 g/d enriched (plant stanol group, n=46) or not (control group, n=46) with plant stanol 3g/d as ester for 6 months. Fasting blood samples were drawn at baseline and at the end of the study. Serum PCSK9 concentration was analyzed with Quantikine Elisa Immunoassay, serum and lipoprotein lipids enzymatically, and serum non-cholesterol sterols with gas-liquid chromatography. At baseline, PCSK9 concentration varied from 91 to 716 ng/mL with a mean value of 278±11 (SEM) ng/mL with no gender difference. It correlated with serum and LDL cholesterol, serum triglycerides, age, BMI, and plasma glucose concentration, but not with variables of cholesterol metabolism when adjusted to serum cholesterol. Plant stanols reduced LDL cholesterol by 10% from controls (p
Source: Clinical Science - Category: Biomedical Science Authors: Source Type: research

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AbstractObjectivesTo explore incidence and progression of coronary atherosclerosis and identify determinants thereof in patients with rheumatoid arthritis. We specifically evaluated the impact of inflammation, cardiac risk factors, duration of medication exposure and their interactions on coronary plaque progression.MethodsOne hundred ‐one participants with a baseline coronary computed tomography angiography underwent follow‐up assessment in 83±3.6 months. Plaque burden was reported as segment involvement score (SIS) describing the number of coronary segments with plaque and segment stenosis score (SSS) characte...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: FULL LENGTH Source Type: research
People take longer to seek help for gradual-onset than abrupt MI symptoms – both are a medical emergency Related items fromOnMedica Hospitals failing to prevent cardiac arrests GPs defend practice on prescribing statins Pharmacists could offer high-dose statins direct to patients Should we recognise obesity as a disease? WHO dietary fat guidance fails to consider crucial evidence
Source: OnMedica Latest News - Category: UK Health Source Type: news
Gastric cancer incidence and death half as likely over 22 years after short-term H. pylori treatment Related items fromOnMedica Antivirals cut liver cancer risk after hepatitis C Statins might not cut colorectal cancer risk after all Antibiotics, H2RAs and PPIs linked to child obesity Long-term use of PPIs linked to doubling in stomach cancer risk Taking aspirin with a PPI reduces risk of oesophageal cancer
Source: OnMedica Latest News - Category: UK Health Source Type: news
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling. Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/ Researchers her...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
GPs concerned about risks of overdiagnosis and over-treatment – NHS interventions must be evidence based Related items fromOnMedica GPs defend practice on prescribing statins Type 2 diabetes in 10 times more young people than realised Should we recognise obesity as a disease? Doctors campaign against ‘too much medicine’ Fund specialist dementia training to improve care and save money
Source: OnMedica Latest News - Category: UK Health Source Type: news
In this study, the modulation of gut microbiota by statins (cholesterol-lowering drugs: atorvastatin and rosuvastatin) was investigated in an aged mouse model of high-fat diet-induced obesity, and the association between gut microbiota and immune responses was described. Atorvastatin and rosuvastatin significantly increased the abundance of the genera Bacteroides, Butyricimonas, and Mucispirillum. Moreover, the abundance of these genera was correlated with the inflammatory response, including levels of IL-1β and TGFβ1 in the ileum. In addition, oral fecal microbiota transplantation with fecal material collected f...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
For decades, doctors have known that losing weight can significantly lower risk of heart disease and by extension, reduce the risk of dying from heart-related events such as stroke and heart attack. Studies have shown that both lifestyle changes including diet and exercise as well as medications and weight-loss surgery can improve heart disease risk factors such as obesity and diabetes, for example, but data supporting the benefits of any of these approaches in actually lowering rates of heart events such as heart attack and atrial fibrillation, or in reducing early deaths from heart disease, have been less robust. The dat...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized diabetes Heart Disease Source Type: news
Inflammation and elevated blood lipids are associated with infertility. Aspirin and statin therapy may improve infertility treatment outcomes among overweight and obese women with systemic inflammation, but li...
Source: Reproductive Health - Category: OBGYN Authors: Tags: Research Source Type: research
In conclusion, in the absence of obesity, visceral adipose tissue possesses a pronounced anti-inflammatory phenotype during aging which is further enhanced by exercise. Methods of Inducing Cellular Damage are Rarely Relevant to Aging, and the Details Matter https://www.fightaging.org/archives/2019/08/methods-of-inducing-cellular-damage-are-rarely-relevant-to-aging-and-the-details-matter/ One of the major challenges in aging research is determining whether or not models of cellular or organismal damage and its consequences are in any way relevant to the natural processes of aging. One can hit a brick with...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Coronary atherosclerosis risk is strongly associated with elevated levels of low-density lipoprotein cholesterol (LDL-C).1 Elevated serum triglycerides are also associated with increased coronary risk, but controversy exists over whether triglycerides (TGs) themselves are atherogenic or merely reflect a surrogate marker for other cardiometabolic disorders including low high-density lipoprotein cholesterol (HDL-C), diabetes mellitus, and obesity.2-5 An important clinical question is whether patients at high atherogenic risk, currently on statin medication, need additional specific treatment for hypertriglyceridemia if it is present.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Editorial Source Type: research
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