Serum proprotein convertase subtilisin/kexin type 9 concentration is not increased by plant stanol ester consumption in normo- to moderately hypercholesterolemic non-obese subjects. The Blood Flow intervention study

Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates LDL cholesterol metabolism by targeting LDL receptors for degradation. Statins increase serum PCSK9 concentration limiting the potential of statins to reduce LDL cholesterol, whereas ezetimibe, inhibitor of cholesterol absorption, has ambiguous effects on circulating PCSK9 levels. Plant stanols also reduce cholesterol absorption, but their effect on serum PCSK9 concentration is not known. Therefore, we performed a controlled, randomized, double-blind study, in which 92 normo- to moderately hypercholesterolemic subjects (35 males and 57 females) consumed vegetable-oil spread 20 g/d enriched (plant stanol group, n=46) or not (control group, n=46) with plant stanol 3g/d as ester for 6 months. Fasting blood samples were drawn at baseline and at the end of the study. Serum PCSK9 concentration was analyzed with Quantikine Elisa Immunoassay, serum and lipoprotein lipids enzymatically, and serum non-cholesterol sterols with gas-liquid chromatography. At baseline, PCSK9 concentration varied from 91 to 716 ng/mL with a mean value of 278±11 (SEM) ng/mL with no gender difference. It correlated with serum and LDL cholesterol, serum triglycerides, age, BMI, and plasma glucose concentration, but not with variables of cholesterol metabolism when adjusted to serum cholesterol. Plant stanols reduced LDL cholesterol by 10% from controls (p
Source: Clinical Science - Category: Biomedical Science Authors: Source Type: research

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AbstractObjectivesTo explore incidence and progression of coronary atherosclerosis and identify determinants thereof in patients with rheumatoid arthritis. We specifically evaluated the impact of inflammation, cardiac risk factors, duration of medication exposure and their interactions on coronary plaque progression.MethodsOne hundred ‐one participants with a baseline coronary computed tomography angiography underwent follow‐up assessment in 83±3.6 months. Plaque burden was reported as segment involvement score (SIS) describing the number of coronary segments with plaque and segment stenosis score (SSS) characte...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: FULL LENGTH Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: OnMedica Latest News - Category: UK Health Source Type: news
In this study, the modulation of gut microbiota by statins (cholesterol-lowering drugs: atorvastatin and rosuvastatin) was investigated in an aged mouse model of high-fat diet-induced obesity, and the association between gut microbiota and immune responses was described. Atorvastatin and rosuvastatin significantly increased the abundance of the genera Bacteroides, Butyricimonas, and Mucispirillum. Moreover, the abundance of these genera was correlated with the inflammatory response, including levels of IL-1β and TGFβ1 in the ileum. In addition, oral fecal microbiota transplantation with fecal material collected f...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
For decades, doctors have known that losing weight can significantly lower risk of heart disease and by extension, reduce the risk of dying from heart-related events such as stroke and heart attack. Studies have shown that both lifestyle changes including diet and exercise as well as medications and weight-loss surgery can improve heart disease risk factors such as obesity and diabetes, for example, but data supporting the benefits of any of these approaches in actually lowering rates of heart events such as heart attack and atrial fibrillation, or in reducing early deaths from heart disease, have been less robust. The dat...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized diabetes Heart Disease Source Type: news
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Source: Reproductive Health - Category: OBGYN Authors: Tags: Research Source Type: research
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Coronary atherosclerosis risk is strongly associated with elevated levels of low-density lipoprotein cholesterol (LDL-C).1 Elevated serum triglycerides are also associated with increased coronary risk, but controversy exists over whether triglycerides (TGs) themselves are atherogenic or merely reflect a surrogate marker for other cardiometabolic disorders including low high-density lipoprotein cholesterol (HDL-C), diabetes mellitus, and obesity.2-5 An important clinical question is whether patients at high atherogenic risk, currently on statin medication, need additional specific treatment for hypertriglyceridemia if it is present.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Editorial Source Type: research
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