Serum proprotein convertase subtilisin/kexin type 9 concentration is not increased by plant stanol ester consumption in normo- to moderately hypercholesterolemic non-obese subjects. The Blood Flow intervention study

In conclusion, the present study demonstrated for the first time that inhibition of cholesterol absorption with plant stanol esters did not affect serum PCSK9 concentration. Thus, plant stanol esters provide an efficient dietary means to lower LDL cholesterol without interfering with the PCSK9 metabolism and in this regard the LDL receptor-mediated cellular cholesterol uptake and removal.

Source: Clinical Science - April 10, 2015 Category: Biomedical Science Authors: P Simonen, U Stenman, H Gylling Source Type: research