In vivo evaluation of anticryptosporidial effects of wheat germ extracts in immunocompromised mice

This study was done to evaluate the possible role of wheat germ extracts inCryptosporidium parvum (C. parvum) infected immunocompromised mice. Thirty white albino mice were classified into six groups as follow: four study groups, all immunosuppressed and infected withC. parvum oocysts. These four groups received treatments as follow:Group (I): treated with nitazoxanide.Group (II): treated with wheat germ oil.Group (III): treated with wheat germ extracted by hexane.Group (IV): treated with wheat germ extracted by ethanol. The remaining two groups were immunosuppressed control groups as follow:Group (V): only infected with C. parvum oocysts (Positive control).Group (VI): non-infected (Negative control). Stool samples were collected and examined to detect oocyst and the ileocecal region was subjected to histopathological and immunohistochemical examination. Wheat germ extracts showed a statistically significant effect againstC. parvum specially wheat germ oil withP value:  <  0.001, this effect was also confirmed by pathological and immunohistochemical examinations.C. parvum has an influence on human health by its effect in diarrheal disease. Wheat germ oil and its extracts has proved to be a reliable herb forC. parvum. treatment confirmed by different methodologies.
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research