m6A methyltransferase METTL3 participated in sympathetic neural remodeling post-MI via the TRAF6/NF- κB pathway and ROS production

Sudden cardiac death caused by ventricular arrhythmias (VAs) is the main cause of high mortality in patients with myocardial infarction (MI). Sympathetic neural remodeling caused by inflammation after MI is closely associated with the occurrence of VAs. METTL3, the earliest identified m6A methyltransferase, is critical in mediating inflammatory responses. Our aim was to investigate whether the m6A methyltransferase METTL3 was involved in sympathetic remodeling post-MI and its specific mechanism.

Source: Journal of Molecular and Cellular Cardiology - June 16, 2022 Category: Cytology Authors: Lei Qi, Ye Wang, Hui Hu, Pingjiang Li, Hesheng Hu, Yan Li, Kang Wang, Yuepeng Zhao, Meng Feng, Hangji Lyu, Jie Yin, Yugen Shi, Yu Wang, Xiaolu Li, Suhua Yan Source Type: research