Neuropathy and Muscle Cramps in Autologous and Allogeneic Hematopoietic Cell Transplantation Survivors

Hematopoietic cell transplantation (HCT) is a critical part of the armamentarium in the treatment of many hematologic malignancies. However, both allogeneic and autologous HCT may be associated with high morbidity in survivors. Neurological complications of HCT that may have long-term impact on quality of life (QOL) are often overlooked.1 Both the central nervous system (CNS) and peripheral nervous system (PNS) can be involved with CNS complications including infections, posterior reversible encephalopathy syndrome (PRES), seizures, and stroke being more prominent in the acute post-HCT period,2 and PNS complications such as peripheral neuropathy, muscle disorders, and rarely myasthenia gravis frequently being long-standing.

Source: Biology of Blood and Marrow Transplantation - June 15, 2022 Category: Hematology Authors: Tanya Lehky, Iago Pinal Fernandez, Elizabeth F. Krakow, Laura Connelly-Smith, Rachel B. Salit, Phuong Vo, Masumi Ueda Oshima, Lynn Onstad, Paul A. Carpenter, Mary E. Flowers, Stephanie J Lee Source Type: research