IJERPH, Vol. 19, Pages 7235: Concept for the Evaluation of Carcinogenic Substances in Population-Based Human Biomonitoring

IJERPH, Vol. 19, Pages 7235: Concept for the Evaluation of Carcinogenic Substances in Population-Based Human Biomonitoring International Journal of Environmental Research and Public Health doi: 10.3390/ijerph19127235 Authors: Klaus-Michael Wollin Petra Apel Yvonni Chovolou Ulrike Pabel Thomas Schettgen Marike Kolossa-Gehring Claudia Röhl on behalf of the Human Biomonitoring Commission of the German Environment The Human Biomonitoring (HBM) Commission at the German Environment Agency holds the opinion that for environmental carcinogens for which no exposure levels can be assumed and are harmless to health, health-based guidance values corresponding to the classical definition of the HBM-I or HBM-II value cannot be established. Therefore, only reference values have been derived so far for genotoxic carcinogens from exposure data of the general population or subpopulations. The concept presented here opens up the possibility of performing health risk assessments of carcinogenic substances in human biomonitoring, and thus goes decisively beyond the purely descriptive statistical reference value concept. Using the presented method, quantitative dose descriptors of internal exposure can be derived from those of external exposure, provided that sufficient toxicokinetic information is available. Dose descriptors of internal exposure then allow the simple estimate of additional lifetime cancer risks for measured biomarker concentrations or, conversely, of equiv...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Concept Paper Source Type: research