PIK3CA mutations in the endocrine organs

PIK3CA encodes a vital component of PI3K-AKT signalling and is commonly mutated in many cancers. Its role has been most well-studied in thyroid neoplasia, demonstrating an association with more aggressive behaviour. The literature surrounding PIK3CA mutations is less well-established in parathyroid, adrenal and pituitary neoplasia. In the parathyroid and adrenal glands it appears more commonly mutated in carcinomas rather than benign neoplasia. In the pituitary, PIK3CA mutations have been identified in neuroendocrine tumours, more commonly in those with invasive growth.
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Mini-symposium: Endocrine Pathology: Single-gene Impacts Source Type: research