Child with bullous lesions of the skin
A seven-year-old female presented to the pediatric emergency department with leg lesions for more than a year. The lesions started out as dusky, pruritic patches mainly on the lower legs. After a course of triamcinolone ointment, she developed blisters on the legs, arms, and trunk. She was then started on clindamycin by her primary care physician due to concern for skin infection. After an evaluation by a dermatologist, she was diagnosed with eczema and the clindamycin was discontinued. She then began treatment with topical crisaborole ointment, monoclonal antibody ustekinumab (human interleukin-12 and -23 antagonist), dip...
Source: The Journal of Emergency Medicine - February 28, 2023 Category: Emergency Medicine Authors: Nehal Bhandari, Jacinta E Cooper Tags: Visual Diagnosis in Emergency Medicine Source Type: research
Urticaria Multiforme
A 12-month-old girl presented to the emergency department with a 4-day history of a pruritic rash over her face, torso, and extremities along with 1-day of fever and swelling of the face and extremities. The child was initially diagnosed with an allergic reaction and subsequently erythema multiforme. She received diphenhydramine and antibiotics without improvement. One week prior to the onset of the rash, the child received her 6-month catch-up immunizations. Physical examination revealed generalized annular, erythematous wheals with dusky centers. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 21, 2023 Category: Pediatrics Authors: Danielle M. Jones, Adrianna E. Sosa, Vini Vijayan Tags: Insights and Images Source Type: research
Evaluation of noscapine-licorice combination effects on cough relieving in COVID-19 outpatients: A randomized controlled trial
Conclusion: Noscapine plus licorice syrup was slightly superior to diphenhydramine in relieving cough symptoms and dyspnea in the COVID-19 outpatients. The severity of cough and cough-related quality of life were also significantly better in the noscapine plus licorice syrup. Noscapine plus licorice may be a valuable treatment in relieving cough in COVID-19 outpatients. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 17, 2023 Category: Drugs & Pharmacology Source Type: research
A Hematological and Histopathological Study on Diphenhydramine Nasal Nano-gel and Nano-emulgel for the Management of Allergic Rhinitis in Animal Model
In this study, we conducted experiment on New Zealand white male rabbits to prove our hypothesis that nasal diphenhydramine nano-gel and nano-emulgel can penetrate the nasal mucosa faster to show drug response and subside histaminic symptoms than market nasal spray (as reference). Blood samples from 48 New Zealand white male rabbits, under both experimental conditions (physiological and pathological) divided into four groups for each (n = 6) were investigated after inducing each dosage form intranasally. Hematologic parameters (WBCs, RBCs, HGB, PLTs, lymphocytes, monocytes, eosinophils, granulocyte counts) were analyzed in...
Source: AAPS PharmSciTech - February 9, 2023 Category: Drugs & Pharmacology Authors: Hina Javed Syed Nisar Hussain Shah Furqan Muhammad Iqbal Nida Javed Benish Saeed Source Type: research
A Hematological and Histopathological Study on Diphenhydramine Nasal Nano-gel and Nano-emulgel for the Management of Allergic Rhinitis in Animal Model
In this study, we conducted experiment on New Zealand white male rabbits to prove our hypothesis that nasal diphenhydramine nano-gel and nano-emulgel can penetrate the nasal mucosa faster to show drug response and subside histaminic symptoms than market nasal spray (as reference). Blood samples from 48 New Zealand white male rabbits, under both experimental conditions (physiological and pathological) divided into four groups for each (n = 6) were investigated after inducing each dosage form intranasally. Hematologic parameters (WBCs, RBCs, HGB, PLTs, lymphocytes, monocytes, eosinophils, granulocyte counts) were analyzed in...
Source: AAPS PharmSciTech - February 9, 2023 Category: Drugs & Pharmacology Authors: Hina Javed Syed Nisar Hussain Shah Furqan Muhammad Iqbal Nida Javed Benish Saeed Source Type: research
A Hematological and Histopathological Study on Diphenhydramine Nasal Nano-gel and Nano-emulgel for the Management of Allergic Rhinitis in Animal Model
In this study, we conducted experiment on New Zealand white male rabbits to prove our hypothesis that nasal diphenhydramine nano-gel and nano-emulgel can penetrate the nasal mucosa faster to show drug response and subside histaminic symptoms than market nasal spray (as reference). Blood samples from 48 New Zealand white male rabbits, under both experimental conditions (physiological and pathological) divided into four groups for each (n = 6) were investigated after inducing each dosage form intranasally. Hematologic parameters (WBCs, RBCs, HGB, PLTs, lymphocytes, monocytes, eosinophils, granulocyte counts) were analyzed in...
Source: AAPS PharmSciTech - February 9, 2023 Category: Drugs & Pharmacology Authors: Hina Javed Syed Nisar Hussain Shah Furqan Muhammad Iqbal Nida Javed Benish Saeed Source Type: research
A Hematological and Histopathological Study on Diphenhydramine Nasal Nano-gel and Nano-emulgel for the Management of Allergic Rhinitis in Animal Model
In this study, we conducted experiment on New Zealand white male rabbits to prove our hypothesis that nasal diphenhydramine nano-gel and nano-emulgel can penetrate the nasal mucosa faster to show drug response and subside histaminic symptoms than market nasal spray (as reference). Blood samples from 48 New Zealand white male rabbits, under both experimental conditions (physiological and pathological) divided into four groups for each (n = 6) were investigated after inducing each dosage form intranasally. Hematologic parameters (WBCs, RBCs, HGB, PLTs, lymphocytes, monocytes, eosinophils, granulocyte counts) were analyzed in...
Source: AAPS PharmSciTech - February 9, 2023 Category: Drugs & Pharmacology Authors: Hina Javed Syed Nisar Hussain Shah Furqan Muhammad Iqbal Nida Javed Benish Saeed Source Type: research
Diphenhydramine
(Source: Reactions Weekly)
Source: Reactions Weekly - February 1, 2023 Category: Drugs & Pharmacology Source Type: research
Oculogyric Crisis after Initiation of Aripiprazole: A Case Report of an Active Duty Service Member
CONCLUSION: Aripiprazole-induced acute dystonia, specifically OGC, is a rare potential adverse effect of aripiprazole. Risk factors include male gender, young age, use of typical antipsychotics, and initiation or uptitration of an antipsychotic. Even though atypical antipsychotics including aripiprazole are associated with lower risk for extrapyramidal symptoms, the possibility of oculogyric dystonia merits close monitoring especially in young, male, and drug naive patients. Anticholinergic agents such as diphenhydramine can treat symptoms of acute dystonia.PMID:36660180 | PMC:PMC9845035 | DOI:10.1155/2023/9440028 (Source:...
Source: Case Reports in Psychiatry - January 20, 2023 Category: Psychiatry Authors: Nicole L Hadler Yevin A Roh David A Nissan Source Type: research
