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The effect of adduction energy and intramolecular bonding in the mobility of dextromethorphan and diphenhydramine with 2-butanol in the buffer gas in ion mobility spectrometry
Publication date: Available online 18 September 2017 Source:Microchemical Journal Author(s): Dairo Meza-Morelos, Roberto Fernandez-Maestre Ion mobility spectrometry (IMS) separates gas-phase ions moving under an electric field according to their size to charge ratio. We used electrospray ionization IMS-mass spectrometry and computational chemistry to study the mobility shifts of the drugs dextromethorphan (Dx) and diphenhydramine (Dy) with the introduction of 2-butanol (B) as a shift reagent (SR) caused by non-covalent adduction of Dx and Dy with B. The binding energies of 2-butanol-ion adducts were calculated using Gauss...
Source: Microchemical Journal - September 19, 2017 Category: Chemistry Source Type: research

Practitioner Review: Treatment of chronic insomnia in children and adolescents with neurodevelopmental disabilities
ConclusionsHere, we provided a tentative guide for the use of drugs for insomnia in children with NDDs. Well‐controlled studies employing both objective polysomnography and subjective sleep measures are needed to determine the efficacy, effectiveness, and safety of the currently prescribed pediatric sleep medicines in children with NDDs. (Source: Journal of Child Psychology and Psychiatry)
Source: Journal of Child Psychology and Psychiatry - September 18, 2017 Category: Psychiatry Authors: Oliviero Bruni, Marco Angriman, Fabrizio Calisti, Alessandro Comandini, Giovanna Esposito, Samuele Cortese, Raffaele Ferri Tags: Practitioner Review Source Type: research

Chronic Spontaneous Urticaria: Pathogenesis and Treatment Considerations.
Authors: Kaplan AP Abstract The treatment of chronic spontaneous urticaria begins with antihistamines; however, the dose required typically exceeds that recommended for allergic rhinitis. Second-generation, relatively non-sedating H₁-receptor blockers are typically employed up to 4 times a day. First-generation antihistamines, such as hydroxyzine or diphenhydramine (Atarax or Benadryl), were employed similarly in the past. Should high-dose antihistamines fail to control symptoms (at least 50%), omalizumab at 300 mg/month is the next step. This is effective in 70% of antihistamine-refractory patients. H₂-recepto...
Source: Allergy, Asthma and Immunology Research - September 17, 2017 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Lipid emulsion therapy for diphenhydramine toxicity
Publication date: Available online 15 September 2017 Source:Journal of the Formosan Medical Association Author(s): Ju-Tae Sohn (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - September 16, 2017 Category: General Medicine Source Type: research

Drugs for Cognitive Loss and Dementia
Date: September 25, 2017 Issue #:  1530Summary:  Alzheimer's disease (AD) is the most common cause of dementia, but cognitive loss is also associated with other neurological conditions such as Parkinson's disease, dementia with Lewy bodies, vascular dementia, and frontotemporal dementia. (Source: The Medical Letter)
Source: The Medical Letter - September 6, 2017 Category: Drugs & Pharmacology Authors: admin Tags: Alzheimer ' s disease Antidepressants Antipsychotics Aricept Benadryl Celexa Citalopram dextromethrophan diphenhydramine Ditropan Donepezil Ebixa Exelon Galantamine Herbals Imipramine Memantine Namenda Namzaric Nu Source Type: research

Expedited Development of Diphenhydramine Orally Disintegrating Tablet through Integrated Crystal and Particle Engineering
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.7b00423 (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - September 6, 2017 Category: Drugs & Pharmacology Authors: Chenguang Wang, Shenye Hu and Changquan Calvin Sun Source Type: research

Nicotine transport in lung and non-lung epithelial cells
Publication date: 1 November 2017 Source:Life Sciences, Volume 188 Author(s): Mikihisa Takano, Hidetaka Kamei, Machi Nagahiro, Masashi Kawami, Ryoko Yumoto Aims Nicotine is rapidly absorbed from the lung alveoli into systemic circulation during cigarette smoking. However, mechanism underlying nicotine transport in alveolar epithelial cells is not well understood to date. In the present study, we characterized nicotine uptake in lung epithelial cell lines A549 and NCI-H441 and in non-lung epithelial cell lines HepG2 and MCF-7. Materials and methods Characteristics of [3 H]nicotine uptake was studied using these cell lines....
Source: Life Sciences - September 6, 2017 Category: Biology Source Type: research

Double-Track Electrochemical Green Approach for Simultaneous Dissolution Profiling of Naproxen Sodium and Diphenhydramine Hydrochloride
Publication date: 30 November 2017 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 146 Author(s): Mostafa A. Shehata, Esraa M. Fawaz, Mohamed K.Abd El-Rahman, Ezzat M. Abdel-Moety Acquisition of the dissolution profiles of more than single active ingredient in a multi-analyte pharmaceutical formulation is a mandatory manufacturing practice that is dominated by utilization of the off-line separation-based chromatographic methods. This contribution adopts a new “Double-Track” approach with the ultimate goal of advancing the in-line potentiometric sensors to their most effective applicability for...
Source: Journal of Pharmaceutical and Biomedical Analysis - September 5, 2017 Category: Drugs & Pharmacology Source Type: research

Thermal degradation of five veterinary and human pharmaceuticals using pyrolysis-GC/MS
Publication date: Available online 30 August 2017 Source:Journal of Analytical and Applied Pyrolysis Author(s): Lei Tian, Stéphane Bayen, Varoujan Yaylayan Veterinary drug residues and, more recently, pharmaceutically active contaminants have been detected in food. In this research, the thermal stability of five pharmaceutically active compounds commonly detected in food (chloramphenicol, florfenicol, lincomycin hydrochloride, diphenhydramine hydrochloride, and carbamazepine) was investigated using Pyrolysis-gas chromatography-mass spectrometry (Py-GC/MS). A range of degradation products observed with this techniqu...
Source: Journal of Analytical and Applied Pyrolysis - August 31, 2017 Category: Chemistry Source Type: research

The Cytochrome P450 Enzyme Responsible For The Production of Z-Norendoxifen In Vitro.
CONCLUSION: Norendoxifen, metabolism from endoxifen by multiple P450s that including CYP3A5. This article is protected by copyright. All rights reserved. PMID: 28834279 [PubMed - as supplied by publisher] (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - August 17, 2017 Category: Biochemistry Authors: Tang D, Chu Z, Bo Li Lu J, Liu J, Zhang Q Tags: Chem Biodivers Source Type: research

Multi-walled Carbon Nanotubes Reduce Toxicity of Diphenhydramine to Ceriodaphnia dubia in Water and Sediment Exposures.
Abstract Multi-walled carbon nanotubes are adsorptive materials that have potential for remediation of organic contaminants in water. Sediment elutriate exposures were undertaken with Ceriodaphnia dubia to compare the toxic effects of diphenhydramine in the presence and absence of sediment and multi-walled carbon nanotubes. In both sediment and solution-only treatments, addition of 0.318 mg/g of carbon nanotubes significantly decreased 48-h mortality relative to control, with a 78.7%-90.1% reduction in treatments with nanotube-amended sediment and 40.7%-53.3% reduction in nanotube-amended water exposures. The...
Source: Bulletin of Environmental Contamination and Toxicology - August 9, 2017 Category: Environmental Health Authors: Myer MH, Black MC Tags: Bull Environ Contam Toxicol Source Type: research

Chlorpheniramine Increases Paracellular Permeability to Marker Fluorescein Lucifer Yellow Mediated by Internalization of Occludin in Murine Colonic Epithelial Cells.
Abstract Ions, small molecules, and drugs are absorbed in the intestinal epithelium mediated by transcellular and paracellular pathways. The function of various transporters expressing in the apical and basolateral membranes of intestinal epithelial cells has been well characterized. In contrast, claudins and occludin, components of the tight junctions (TJs), determine the paracellular permeability to ions and low molecular weight compounds, but the properties for permeability has not been clarified in detail. In the present study, we examined the effects of anti-histamine drugs, chlorpheniramine and diphenhydrami...
Source: Biological and Pharmaceutical Bulletin - August 6, 2017 Category: Drugs & Pharmacology Authors: Manabe A, Furukawa C, Endo S, Marunaka K, Nishiyama T, Fujii N, Tabuchi Y, Matsunaga T, Ikari A Tags: Biol Pharm Bull Source Type: research

Black ant stings caused by Pachycondyla sennaarensis: a significant health hazard
We present a series of cases of allergic reactions following insect bites or stings that presented to our emergency department and that were caused by the black samsum ant (Pachycondyla sennaarensis). Reactions ranged from mild allergic reactions to severe anaphylactic shock. Patients were treated with subcutaneous epinephrine 0.3 mg, intravenous methylprednisolone 125 mg, intravenous diphenhydramine HCl 50 mg, and intravenous normal saline as appropriate. These cases illustrate the range of clinical presentations to black ant stings, which can include severe reactions, indicating that ant stings are a significant public h...
Source: Annals of Saudi Medicine - July 31, 2017 Category: General Medicine Tags: ISSUE 3 Source Type: research

Transient Fetal Tachycardia After Intravenous Diphenhydramine Administration.
CONCLUSION: Diphenhydramine may produce transient fetal tachycardia as well as increased maternal uterine activity. PMID: 28697105 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - July 7, 2017 Category: OBGYN Authors: Abernathy A, Alsina L, Greer J, Egerman R Tags: Obstet Gynecol Source Type: research

Preclinical safety and efficacy of andexanet alfa in animal models.
CONCLUSIONS: These data suggest that andexanet is a promising therapy for the reversal of FXa inhibitor-induced anticoagulation, supporting clinical studies in humans. This article is protected by copyright. All rights reserved. PMID: 28682477 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 6, 2017 Category: Hematology Authors: Lu G, Hollenbach SJ, Baker DC, Tan S, Hutchaleelaha A, Curnutte JT, Conley PB Tags: J Thromb Haemost Source Type: research

Preclinical safety and efficacy of andexanet alfa in animal models
ConclusionsThese data suggest that andexanet is a promising therapy for the reversal of FXa inhibitor‐induced anticoagulation, supporting clinical studies in humans.This article is protected by copyright. All rights reserved. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - July 1, 2017 Category: Hematology Authors: G. Lu, S. J. Hollenbach, D. C. Baker, S. Tan, A. Hutchaleelaha, J. T. Curnutte, P. B. Conley Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

Safety profile of H1 ‐antihistamines in pediatrics: an analysis based on data from VigiBase
ConclusionsH1‐antihistamines are among the most used drugs in pediatrics, also in an off‐label manner. Our data highlights associations with serious and unexpected ADRs. Educative intervention to clinicians and parents are needed to help doctors to make proper choices on the drug treatment and for the early detection of ADRs to maximize the benefits and reduce the risk of ADRs in these patients. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - June 27, 2017 Category: Drugs & Pharmacology Authors: Domenico Motola, Monia Donati, Chiara Biagi, Elisabetta Calamelli, Francesca Cipriani, Mauro Melis, Luca Monaco, Alberto Vaccheri, Giampaolo Ricci Tags: ORIGINAL REPORT Source Type: research

Intravenous Ferumoxytol in Pediatric Patients With Iron Deficiency Anemia.
Abstract BACKGROUND: Iron deficiency anemia (IDA) is common in children. Limited data exist on the efficacy and safety of ferumoxytol in children. OBJECTIVE: To assess the efficacy of 10 mg/kg dose given over 15-60 minutes in correcting IDA and report any adverse drug reactions (ADRs). METHODS: We conducted a retrospective review of all patients who received ferumoxytol infusions for the management of IDA by the Pediatric Blood Management Program between October 2010 and March 2015. RESULTS: A total of 110 infusions were given to 54 patients. Compared with baseline preinfusion hemoglobin (Hb; 9.2 &p...
Source: The Annals of Pharmacotherapy - June 18, 2017 Category: Drugs & Pharmacology Authors: Hassan N, Boville B, Reischmann D, Ndika A, Sterken D, Kovey K Tags: Ann Pharmacother Source Type: research

Process Modeling, Simulation, and Technoeconomic Evaluation of Separation Solvents for the Continuous Pharmaceutical Manufacturing (CPM) of Diphenhydramine
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.6b00386 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - June 16, 2017 Category: Chemistry Authors: Samir Diab and Dimitrios I. Gerogiorgis Source Type: research

Over-the-counter medications containing diphenhydramine and doxylamine used by older adults to improve sleep, a Letter
(Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - June 15, 2017 Category: Drugs & Pharmacology Source Type: research

Event-related potentials reflect impaired temporal interval learning following haloperidol administration
ConclusionsOur results support a functional and neurobiological dissociation between the ERN and FRN. (Source: Psychopharmacology)
Source: Psychopharmacology - June 10, 2017 Category: Psychiatry Source Type: research

Safety Profile of Cough and Cold Medication Use in Pediatrics
We describe the safety profile of CCMs in children
Source: PEDIATRICS - June 1, 2017 Category: Pediatrics Authors: Green, J. L., Wang, G. S., Reynolds, K. M., Banner, W., Bond, G. R., Kauffman, R. E., Palmer, R. B., Paul, I. M., Dart, R. C. Tags: Injury, Violence & Poison Prevention, Hazardous Exposure, Public Health Article Source Type: research

Diphenhydramine inhibits voltage-gated proton channels (Hv1) and induces acidification in leukemic Jurkat T cells- New insights into the pro-apoptotic effects of antihistaminic drugs.
Authors: Asuaje A, Martín P, Enrique N, Díaz Zegarra LA, Smaldini P, Docena G, Milesi V Abstract An established characteristic of neoplastic cells is their metabolic reprogramming, known as the Warburg effect, with greater reliance on energetically less efficient pathways (such as glycolysis and pentose phosphate shunt) compared with oxidative phosphorylation. This results in an overproduction of acidic species that must be extruded to maintain intracellular homeostasis. We recently described that blocking the proton currents in leukemic cells mediated by Hv1 ion channels triggers a marked intracellul...
Source: Channels - May 18, 2017 Category: Molecular Biology Tags: Channels (Austin) Source Type: research

A rapid method to screen poisoning causative agents in an acute care hospital in Japan
ConclusionAs LC‐MS/MS analysis using Monospin C18 can simultaneously and rapidly screen several medicinal toxicants present in blood samples, it is expected to be highly suitable for clinical settings. This article provides an analytical method by LC–MS/MS using a Monospin C18 column for screening poisoning causative agents in acute care hospital in Japan. The method is superior with respect to convenience as compared to the existing methods and it covers a wide range of medicinal toxicants in various strains. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - May 15, 2017 Category: Drugs & Pharmacology Authors: K. Usui, H. Mori, T. Tachi, T. Matsumura, K. Mori, A. Takeda, Y. Noguchi, T. Yoshimura, H. Teramachi Tags: ORIGINAL ARTICLE Source Type: research

Over-the-counter medications containing diphenhydramine and doxylamine used by older adults to improve sleep
Conclusion A majority of older adults in a limited sample from the United States taking an over-the-counter medication to improve sleep are taking a product containing diphenhydramine or doxylamine, both of which are classified as potentially inappropriate for older adults. Awareness of the safety risks of over-the-counter medications and addressing conditions that impact sleep quality could be facilitated through consultation with pharmacists and other healthcare providers. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 2, 2017 Category: Drugs & Pharmacology Source Type: research

Beyond-use dating of lidocaine alone and in two "magic mouthwash" preparations.
CONCLUSION: A BUD of 21 days is recommended for lidocaine prepared with diphenhydramine and aluminum hydroxide-magnesium hydroxide-simethicone in ratios of 1:1:1 and 1:2.5:2.5 and stored at room temperature in amber oral plastic syringes. PMID: 28438825 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - April 26, 2017 Category: Drugs & Pharmacology Authors: Kirk LM, Brown SD, Luu Y, Ogle A, Huffman J, Lewis PO Tags: Am J Health Syst Pharm Source Type: research

Continuous diphenhydramine infusion and imatinib for KIT-D816V-negative mast cell activation syndrome: a case report
ConclusionsContinuous diphenhydramine infusion can provide promising outcomes following the failure of intermittent antihistamine dosing in patients with severe mast cell activation syndrome. Initiating continuous diphenhydramine infusion may be helpful in an intensive care setting when the patient is particularly prone to anaphylaxis and/or the resources needed to manage anaphylaxis are not available outside the intensive care unit. Furthermore, imatinib provides benefits in KIT-D816V-negative mast cell disorders due to other unknown mutations. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 24, 2017 Category: Journals (General) Source Type: research

Acute masseter dystonia in a pediatric patient receiving aripiprazole and methylphenidate following induction of general anesthesia
Summary An 11‐year‐old male receiving aripiprazole, methylphenidate, and clonidine developed acute masseter dystonia inhibiting tracheal intubation after induction of general anesthesia with propofol and rocuronium. Following emergence, he had trismus and jaw discomfort. Psychiatry consultation suspected an acute dystonic reaction, so diphenhydramine was administered intravenously which resolved symptoms. We suspect chronic aripiprazole and methylphenidate usage combined with propofol administration in the short‐term absence of methylphenidate made this patient susceptible to dystonic reactions. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - April 17, 2017 Category: Anesthesiology Authors: Michelle LeRiger, Jasper Williams, Greta Duncan ‐Wiebe, Mohanad Shukry Tags: Case Report Source Type: research

A Rare Case of Paraneoplastic Chorea (P2.023)
Conclusions:In conjunction with one other case reported elsewhere, these findings demonstrate that P/Q type VGCC antibodies may need to be considered in the differential work-up for chorea.Disclosure: Dr. Stoner has nothing to disclose. Dr. Boudouris has nothing to disclose. Dr. Pierce has nothing to disclose. (Source: Neurology)
Source: Neurology - April 17, 2017 Category: Neurology Authors: Stoner, A., Boudouris, W., Pierce, R. Tags: Movement Disorders: Huntington ' s Disease, Chorea & amp;amp; Tardive Dyskinesia Source Type: research

Two cases of acute allergic reaction following injection of generic, government-provided botulinum toxin a (ggp-bta) for hemifacial spasm and blepharospasm (p3.028)
Conclusions:We reported two cases of facial angioedema following injection of GGP-BTA, with resolution after adequate systemic treatment with anti-allergic medications.Disclosure: Dr. Parolin has nothing to disclose. Dr. Germiniani has nothing to disclose. Dr. Teive has nothing to disclose. Dr. Scola has nothing to disclose. Dr. Borges has nothing to disclose. Dr. Parolin has nothing to disclose. Dr. Parolin has nothing to disclose. Dr. Parolin has nothing to disclose. Dr. Parolin has nothing to disclose. Dr. Parolin has nothing to disclose. Dr. Parolin has nothing to disclose. (Source: Neurology)
Source: Neurology - April 17, 2017 Category: Neurology Authors: Parolin, L., Germiniani, F., Teive, H. A., Scola, R., Borges, C., canever, m., scavasine, v., ribas, g., Miksza Tholken, K. F., Brenner, F. M., Serafini, S. Z. Tags: Movement Disorders: Dystonia and Neurotoxin Therapies Source Type: research

Glatiramer Acetate Induced Serum Sickness (P5.393)
Conclusions:The patient described developed signs, symptoms and laboratory data suggestive of serum sickness which was further supported by symptom recurrence with second challenge 21 days after initial cessation. Serum sickness is a type III hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum. The clinical presentation of serum sickness is described as symptoms including fever, rash, arthralgia, nausea, vomiting, headaches and neurologic manifestations which can include peripheral neuropathy or brachial neuritis. Pathophysiologically it takes of 1–2 weeks or longer t...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ferguson, P. Tags: Disease Modifying Therapy for Multiple Sclerosis: Risk Assessment and Safety Source Type: research

Case report: Leukocytoclastic vasculitis in an MS patient following alemtuzumab treatment (P5.403)
Conclusions:Cutaneous leukocytoclastic vasculitis is usually a self-limited, treatable problem which may be idiopathic or associated with medication or multiple disease states. Although alemtuzumab is an effective treatment for MS in many patients, it may be associated with potentially life-threatening thrombocytopenia and patients are closely followed. The present case adds another diagnosis, that of the more benign leukocytoclastic vasculitis, to the differential for post-treatment cutaneous change.Disclosure: Dr. Garten has nothing to disclose. Dr. Edwards has received personal compensation for activities with Biogen an...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Garten, L., Edwards, K., Lezcano, C., Spiro, J., Siuta, J., Belcher, S. Tags: Disease Modifying Therapy for Multiple Sclerosis: Risk Assessment and Safety Source Type: research

Dose-Ranging Effect of Systemic Diphenhydramine on Postoperative Quality of Recovery After Ambulatory Laparoscopic Surgery: A Randomized, Placebo-Controlled, Double-blinded, Clinical Trial
(Abstracted from J Clin Anesth, 34:46–52, 2016) This prospective, randomized, double-blind, placebo-controlled trial was designed to evaluate the dose-ranging effects of diphenhydramine on postoperative quality of recovery (QoR) when used with ondansetron after outpatient laparoscopic gynecologic surgery. The QoR-40 questionnaire (QoR-40) was utilized by a blinded investigator to evaluate patients 24 hours after surgery. (Source: Survey of Anesthesiology)
Source: Survey of Anesthesiology - April 1, 2017 Category: Anesthesiology Tags: General Anesthesia Source Type: research

Diphenhydramine
(Source: Reactions Weekly)
Source: Reactions Weekly - April 1, 2017 Category: Drugs & Pharmacology Source Type: research

Elimination half-life of diphenhydramine in overdose
. (Source: Clinical Toxicology)
Source: Clinical Toxicology - March 28, 2017 Category: Toxicology Authors: Anneka Varma Loretta Ford Neel Patel J Allister Vale Source Type: research

A phase 2 safety study of accelerated elotuzumab infusion, over less than 1 h, in combination with lenalidomide and dexamethasone, in patients with multiple myeloma
Abstract Elotuzumab, an immunostimulatory SLAMF7‐targeting monoclonal antibody, induces myeloma cell death with minimal effects on normal tissue. In a previous phase 3 study in patients with relapsed/refractory multiple myeloma (RRMM), elotuzumab (10 mg/kg, ∼3‐h infusion), combined with lenalidomide and dexamethasone, demonstrated durable efficacy and acceptable safety; 10% (33/321) of patients had infusion reactions (IRs; Grade 1/2: 29; Grade 3: 4). This phase 2 study (NCT02159365) investigated an accelerated infusion schedule in 70 patients with newly diagnosed multiple myeloma or RRMM. The primary endpoint was c...
Source: American Journal of Hematology - March 22, 2017 Category: Hematology Authors: James Berenson, Robert Manges, Suprith Badarinath, Alan Cartmell, Kristi McIntyre, Roger Lyons, Wael Harb, Hesham Mohamed, Ali Nourbakhsh, Robert Rifkin Tags: RESEARCH ARTICLE Source Type: research

Analysis of Disease Activity Categories in Chronic Spontaneous/Idiopathic Urticaria.
CONCLUSION: Categorical UAS7TD disease states can discriminate between measures when considering the impact of urticaria activity. Using five categorical disease states could simplify clinical assessment and monitoring of treatment efficacy. This article is protected by copyright. All rights reserved. PMID: 28295198 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 12, 2017 Category: Dermatology Authors: Stull D, McBride D, Tian H, Gimenez Arnau A, Maurer M, Marsland A, Balp MM, Khalil S, Grattan C Tags: Br J Dermatol Source Type: research

Antidote availability in the municipality of Campinas, S ão Paulo, Brazil.
CONCLUSION:: The stock of antidotes for attending poisoning emergencies in the municipality of Campinas is incomplete and needs to be improved. PMID: 28301629 [PubMed - as supplied by publisher] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - March 12, 2017 Category: Journals (General) Authors: Rodrigues Fernandes LC, Galvão TF, Toledo Ricardi AS, De Capitani EM, Hyslop S, Bucaretchi F Tags: Sao Paulo Med J Source Type: research

Pharmacologic Treatment of Cannabinoid Hyperemesis Syndrome: A Systematic Review
ConclusionHigh‐quality evidence for pharmacologic treatment of CHS is limited. Benzodiazepines, followed by haloperidol and capsaicin, were most frequently reported as effective for acute treatment, and TCAs for long‐term treatment. As the prevalence of CHS increases, future prospective trials are greatly needed to evaluate and further define optimal pharmacologic treatment of patients with CHS.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 1, 2017 Category: Drugs & Pharmacology Authors: John R. Richards, Brent K. Gordon, Aaron R. Danielson, Aimee K. Moulin Tags: Review of Therapeutics Source Type: research

Successful intervention to mitigate an acetylcholinesterase inhibitor ‐induced rhinorrhea prescribing cascade: a case report
We describe an intervention to mitigate a prescribing cascade while continuing a clinically necessary medication without negatively impacting the patient. Case summaryA 77‐year‐old women experienced probable acetylcholinesterase inhibitor‐induced rhinorrhea and subsequently self‐medicated with diphenhydramine which lead to worsening cognitive function. We reduced the dose of the acetylcholinesterase inhibitor and discontinued the diphenhydramine. The symptoms of rhinorrhea were subsequently reduced without negatively impacting cognition. What is new and conclusionThis was the first published prescribing cascade int...
Source: Journal of Clinical Pharmacy and Therapeutics - February 28, 2017 Category: Drugs & Pharmacology Authors: S. M. Vouri, J. M. Chung, E. F. Binder Tags: Case Report Source Type: research

The “Silver Star” Initiative: Proactively Protecting Our Older Adult Population
Topic Significance& Study Purpose/Background/Rationale: BMT recipients aged 65 years or older comprise 30% of patients at this large academic health system. BMT protocols commonly use medications at standardized doses often bringing about the need for aggressive symptom management. Lorazepam, prochlorperazine, promethazine and diphenhydramine are frequently used to treat the nausea, vomiting and diarrhea which often follow BMT conditioning regimens. Literature indicates that geriatric individuals are at a greater risk for medication-related adverse events as described per BEERS and STOP/START criteria. (Source: Biology...
Source: Biology of Blood and Marrow Transplantation - February 22, 2017 Category: Hematology Authors: Jeanne Verrecchio Source Type: research

A phase 2 safety study of accelerated elotuzumab infusion, over less than 1 hour, in combination with lenalidomide and dexamethasone, in patients with multiple myeloma
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 17, 2017 Category: Hematology Authors: James Berenson, Robert Manges, Suprith Badarinath, Alan Cartmell, Kristi McIntyre, Roger Lyons, Wael Harb, Hesham Mohamed, Ali Nourbakhsh, Robert Rifkin Tags: Research Article Source Type: research

Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline
Introduction:The purpose of this guideline is to establish clinical practice recommendations for the pharmacologic treatment of chronic insomnia in adults, when such treatment is clinically indicated. Unlike previous meta-analyses, which focused on broad classes of drugs, this guideline focuses on individual drugs commonly used to treat insomnia. It includes drugs that are FDA-approved for the treatment of insomnia, as well as several drugs commonly used to treat insomnia without an FDA indication for this condition. This guideline should be used in conjunction with other AASM guidelines on the evaluation and treatment of ...
Source: Journal of Clinical Sleep Medicine : JCSM - February 15, 2017 Category: Sleep Medicine Source Type: research

Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data.
Authors: Kanamitsu K, Nozaki Y, Nagaya Y, Sugiyama Y, Kusuhara H Abstract Significant histamine H1 receptor occupation in the central nervous system (CNS) is associated with sedation. Here we examined the time profiles of the H1 receptor occupancy (RO) in the CNS using sedative (diphenhydramine and ketotifen) and non-sedative (bepotastine and olopatadine) antagonists at their therapeutic doses by integrating in vitro and animal data. A pharmacokinetic model was constructed to associate plasma concentrations and receptor binding in the brain. Dissociation and association rate constants with the H1 receptor and ...
Source: Drug Metabolism and Pharmacokinetics - February 14, 2017 Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research

Abstract P3-13-20: Use of a 3-D bioabsorbable tissue marker in 61 patients over two years
Conclusion:The I-SPY 2 adaptive randomization model efficiently evaluates investigational agents in the setting of neoadjuvant BC. The value of I-SPY 2 is that it provides insight as to the regimen's likelihood of success in a phase 3 neoadjuvant study. Although no signature reached the efficacy threshold of 85% likelihood of success in phase 3, we observed the most impact in HR-/HER2- patients, with a 16% improvement in pCR rate. While our data do not support the continued development of Ganetespib alone for neoadjuvant BC, combinations with Ganetespib, which could potentiate its effect, may be worth pursuing in I-SPY 2 o...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: CS Kaufman, W Hall, V Behrndt, G Wolgamot, L Hill, K Zacharias, A Rogers, S Nix, N Schnell Tags: Poster Session Abstracts Source Type: research

Abstract P6-07-22: Association of Hedgehog signaling pathway with luminal B sub-type of breast cancer affected patients of Pakistan
This study evaluated 2 steroid-based mouth rinses for the prevention or amelioration of oral stomatitis in pts with MBC treated with EVE. Methods: This prospective randomized phase II study enrolled postmenopausal pts (planned accrual=100) with HR+ MBC within the US Oncology Network who were initiating therapy with an aromatase inhibitor plus EVE (10 mg/day)(AIE). Pts were randomized 1:1 to prophylactic therapy with 1 of 2 oral rinses (ARM 1: MMW 480 ml recipe: 320 mL oral Benadryl, 2 g Tetracycline, 80 mg Hydrocortisone, 40 mL Nystatin suspension, water; or ARM 2: Prednisolone (P) 15mg/5mL oral solution, 1.8% alcohol). Pt...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: SK Riaz, R Rashid, STA Shah, F Wang, MFA Malik Tags: Poster Session Abstracts Source Type: research

Suppression in Bitterness Intensity of Bitter Basic Drug by Chlorogenic Acid.
This study showed that the bitterness intensity of DPH was suppressed by QNA and CGA through a direct electrostatic interaction with DPH as confirmed in (1)H-NMR spectroscopic analysis. CGA and QNA may therefore be useful bitterness-masking agents for the basic drug DPH. PMID: 28154308 [PubMed - in process] (Source: Chemical and Pharmaceutical Bulletin)
Source: Chemical and Pharmaceutical Bulletin - February 7, 2017 Category: Drugs & Pharmacology Authors: Shiraishi S, Haraguchi T, Nakamura S, Kojima H, Kawasaki I, Yoshida M, Uchida T Tags: Chem Pharm Bull (Tokyo) Source Type: research

Taste-Masking Effect of Chlorogenic Acid (CGA) on Bitter Drugs Evaluated by Taste Sensor and Surface Plasmon Resonance on the Basis of CGA-Drug Interactions.
Abstract The purpose of this study was to evaluate the taste-masking effects of chlorogenic acid (CGA) on bitter drugs using taste sensor measurements and surface plasmon resonance (SPR) analysis of CGA-drug interactions. Six different bitter drugs were used: amlodipine besylate (AMD), diphenhydramine hydrochloride (DPH), donepezil hydrochloride (DNP), rebamipide (RBM), diclofenac sodium (DCF) and etodolac (ETD). Taste sensor outputs were significantly inhibited by the addition of CGA to all drugs. The inhibition ratio of the taste sensor output decreased in the following order DPH>DNP>AMD≈DCF≈RB...
Source: Chemical and Pharmaceutical Bulletin - February 7, 2017 Category: Drugs & Pharmacology Authors: Shiraishi S, Haraguchi T, Nakamura S, Li D, Kojima H, Yoshida M, Uchida T Tags: Chem Pharm Bull (Tokyo) Source Type: research

Face and Neck Swelling Hint at a Daunting Diagnosis
​BY MOHAMMED HASSAN-ALI, MSC, & AHMED RAZIUDDIN, MDA 56-year-old black man presented to the ED complaining of face and neck swelling. An initial history was difficult to obtain because the patient did not speak English fluently and had slurred speech. Symptoms started approximately a week earlier when the patient was at his nursing home. He denied dysphagia or odynophagia, he had no rashes, pruritus, dyspnea, or peripheral edema, his face was flushed, and he had visibly engorged neck veins. He noticed that his tongue was mildly swollen, so he took Benadryl for a week with no relief. The patient said he believed that ...
Source: The Case Files - February 2, 2017 Category: Emergency Medicine Tags: Blog Posts Source Type: research