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Diphenhydramine inhibits voltage-gated proton channels (Hv1) and induces acidification in leukemic Jurkat T cells- New insights into the pro-apoptotic effects of antihistaminic drugs.
Authors: Asuaje A, Martín P, Enrique N, Díaz Zegarra LA, Smaldini P, Docena G, Milesi V Abstract An established characteristic of neoplastic cells is their metabolic reprogramming, known as the Warburg effect, with greater reliance on energetically less efficient pathways (such as glycolysis and pentose phosphate shunt) compared with oxidative phosphorylation. This results in an overproduction of acidic species that must be extruded to maintain intracellular homeostasis. We recently described that blocking the proton currents in leukemic cells mediated by Hv1 ion channels triggers a marked intracellul...
Source: Channels - May 18, 2017 Category: Molecular Biology Tags: Channels (Austin) Source Type: research

A rapid method to screen poisoning causative agents in an acute care hospital in Japan
ConclusionAs LC‐MS/MS analysis using Monospin C18 can simultaneously and rapidly screen several medicinal toxicants present in blood samples, it is expected to be highly suitable for clinical settings. This article provides an analytical method by LC–MS/MS using a Monospin C18 column for screening poisoning causative agents in acute care hospital in Japan. The method is superior with respect to convenience as compared to the existing methods and it covers a wide range of medicinal toxicants in various strains. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - May 15, 2017 Category: Drugs & Pharmacology Authors: K. Usui, H. Mori, T. Tachi, T. Matsumura, K. Mori, A. Takeda, Y. Noguchi, T. Yoshimura, H. Teramachi Tags: ORIGINAL ARTICLE Source Type: research

Over-the-counter medications containing diphenhydramine and doxylamine used by older adults to improve sleep
Conclusion A majority of older adults in a limited sample from the United States taking an over-the-counter medication to improve sleep are taking a product containing diphenhydramine or doxylamine, both of which are classified as potentially inappropriate for older adults. Awareness of the safety risks of over-the-counter medications and addressing conditions that impact sleep quality could be facilitated through consultation with pharmacists and other healthcare providers. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 2, 2017 Category: Drugs & Pharmacology Source Type: research

Beyond-use dating of lidocaine alone and in two "magic mouthwash" preparations.
CONCLUSION: A BUD of 21 days is recommended for lidocaine prepared with diphenhydramine and aluminum hydroxide-magnesium hydroxide-simethicone in ratios of 1:1:1 and 1:2.5:2.5 and stored at room temperature in amber oral plastic syringes. PMID: 28438825 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - April 26, 2017 Category: Drugs & Pharmacology Authors: Kirk LM, Brown SD, Luu Y, Ogle A, Huffman J, Lewis PO Tags: Am J Health Syst Pharm Source Type: research

Continuous diphenhydramine infusion and imatinib for KIT-D816V-negative mast cell activation syndrome: a case report
ConclusionsContinuous diphenhydramine infusion can provide promising outcomes following the failure of intermittent antihistamine dosing in patients with severe mast cell activation syndrome. Initiating continuous diphenhydramine infusion may be helpful in an intensive care setting when the patient is particularly prone to anaphylaxis and/or the resources needed to manage anaphylaxis are not available outside the intensive care unit. Furthermore, imatinib provides benefits in KIT-D816V-negative mast cell disorders due to other unknown mutations. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 24, 2017 Category: Journals (General) Source Type: research

Acute masseter dystonia in a pediatric patient receiving aripiprazole and methylphenidate following induction of general anesthesia
Summary An 11‐year‐old male receiving aripiprazole, methylphenidate, and clonidine developed acute masseter dystonia inhibiting tracheal intubation after induction of general anesthesia with propofol and rocuronium. Following emergence, he had trismus and jaw discomfort. Psychiatry consultation suspected an acute dystonic reaction, so diphenhydramine was administered intravenously which resolved symptoms. We suspect chronic aripiprazole and methylphenidate usage combined with propofol administration in the short‐term absence of methylphenidate made this patient susceptible to dystonic reactions. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - April 17, 2017 Category: Anesthesiology Authors: Michelle LeRiger, Jasper Williams, Greta Duncan ‐Wiebe, Mohanad Shukry Tags: Case Report Source Type: research

A Rare Case of Paraneoplastic Chorea (P2.023)
Conclusions:In conjunction with one other case reported elsewhere, these findings demonstrate that P/Q type VGCC antibodies may need to be considered in the differential work-up for chorea.Disclosure: Dr. Stoner has nothing to disclose. Dr. Boudouris has nothing to disclose. Dr. Pierce has nothing to disclose. (Source: Neurology)
Source: Neurology - April 17, 2017 Category: Neurology Authors: Stoner, A., Boudouris, W., Pierce, R. Tags: Movement Disorders: Huntington ' s Disease, Chorea & amp;amp; Tardive Dyskinesia Source Type: research

Two cases of acute allergic reaction following injection of generic, government-provided botulinum toxin a (ggp-bta) for hemifacial spasm and blepharospasm (p3.028)
Conclusions:We reported two cases of facial angioedema following injection of GGP-BTA, with resolution after adequate systemic treatment with anti-allergic medications.Disclosure: Dr. Parolin has nothing to disclose. Dr. Germiniani has nothing to disclose. Dr. Teive has nothing to disclose. Dr. Scola has nothing to disclose. Dr. Borges has nothing to disclose. Dr. Parolin has nothing to disclose. Dr. Parolin has nothing to disclose. Dr. Parolin has nothing to disclose. Dr. Parolin has nothing to disclose. Dr. Parolin has nothing to disclose. Dr. Parolin has nothing to disclose. (Source: Neurology)
Source: Neurology - April 17, 2017 Category: Neurology Authors: Parolin, L., Germiniani, F., Teive, H. A., Scola, R., Borges, C., canever, m., scavasine, v., ribas, g., Miksza Tholken, K. F., Brenner, F. M., Serafini, S. Z. Tags: Movement Disorders: Dystonia and Neurotoxin Therapies Source Type: research

Glatiramer Acetate Induced Serum Sickness (P5.393)
Conclusions:The patient described developed signs, symptoms and laboratory data suggestive of serum sickness which was further supported by symptom recurrence with second challenge 21 days after initial cessation. Serum sickness is a type III hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum. The clinical presentation of serum sickness is described as symptoms including fever, rash, arthralgia, nausea, vomiting, headaches and neurologic manifestations which can include peripheral neuropathy or brachial neuritis. Pathophysiologically it takes of 1–2 weeks or longer t...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ferguson, P. Tags: Disease Modifying Therapy for Multiple Sclerosis: Risk Assessment and Safety Source Type: research

Case report: Leukocytoclastic vasculitis in an MS patient following alemtuzumab treatment (P5.403)
Conclusions:Cutaneous leukocytoclastic vasculitis is usually a self-limited, treatable problem which may be idiopathic or associated with medication or multiple disease states. Although alemtuzumab is an effective treatment for MS in many patients, it may be associated with potentially life-threatening thrombocytopenia and patients are closely followed. The present case adds another diagnosis, that of the more benign leukocytoclastic vasculitis, to the differential for post-treatment cutaneous change.Disclosure: Dr. Garten has nothing to disclose. Dr. Edwards has received personal compensation for activities with Biogen an...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Garten, L., Edwards, K., Lezcano, C., Spiro, J., Siuta, J., Belcher, S. Tags: Disease Modifying Therapy for Multiple Sclerosis: Risk Assessment and Safety Source Type: research

Dose-Ranging Effect of Systemic Diphenhydramine on Postoperative Quality of Recovery After Ambulatory Laparoscopic Surgery: A Randomized, Placebo-Controlled, Double-blinded, Clinical Trial
(Abstracted from J Clin Anesth, 34:46–52, 2016) This prospective, randomized, double-blind, placebo-controlled trial was designed to evaluate the dose-ranging effects of diphenhydramine on postoperative quality of recovery (QoR) when used with ondansetron after outpatient laparoscopic gynecologic surgery. The QoR-40 questionnaire (QoR-40) was utilized by a blinded investigator to evaluate patients 24 hours after surgery. (Source: Survey of Anesthesiology)
Source: Survey of Anesthesiology - April 1, 2017 Category: Anesthesiology Tags: General Anesthesia Source Type: research

Diphenhydramine
(Source: Reactions Weekly)
Source: Reactions Weekly - April 1, 2017 Category: Drugs & Pharmacology Source Type: research

Elimination half-life of diphenhydramine in overdose
. (Source: Clinical Toxicology)
Source: Clinical Toxicology - March 28, 2017 Category: Toxicology Authors: Anneka Varma Loretta Ford Neel Patel J Allister Vale Source Type: research

A phase 2 safety study of accelerated elotuzumab infusion, over less than 1 h, in combination with lenalidomide and dexamethasone, in patients with multiple myeloma
Abstract Elotuzumab, an immunostimulatory SLAMF7‐targeting monoclonal antibody, induces myeloma cell death with minimal effects on normal tissue. In a previous phase 3 study in patients with relapsed/refractory multiple myeloma (RRMM), elotuzumab (10 mg/kg, ∼3‐h infusion), combined with lenalidomide and dexamethasone, demonstrated durable efficacy and acceptable safety; 10% (33/321) of patients had infusion reactions (IRs; Grade 1/2: 29; Grade 3: 4). This phase 2 study (NCT02159365) investigated an accelerated infusion schedule in 70 patients with newly diagnosed multiple myeloma or RRMM. The primary endpoint was c...
Source: American Journal of Hematology - March 22, 2017 Category: Hematology Authors: James Berenson, Robert Manges, Suprith Badarinath, Alan Cartmell, Kristi McIntyre, Roger Lyons, Wael Harb, Hesham Mohamed, Ali Nourbakhsh, Robert Rifkin Tags: RESEARCH ARTICLE Source Type: research

Analysis of Disease Activity Categories in Chronic Spontaneous/Idiopathic Urticaria.
CONCLUSION: Categorical UAS7TD disease states can discriminate between measures when considering the impact of urticaria activity. Using five categorical disease states could simplify clinical assessment and monitoring of treatment efficacy. This article is protected by copyright. All rights reserved. PMID: 28295198 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 12, 2017 Category: Dermatology Authors: Stull D, McBride D, Tian H, Gimenez Arnau A, Maurer M, Marsland A, Balp MM, Khalil S, Grattan C Tags: Br J Dermatol Source Type: research

Antidote availability in the municipality of Campinas, S ão Paulo, Brazil.
CONCLUSION:: The stock of antidotes for attending poisoning emergencies in the municipality of Campinas is incomplete and needs to be improved. PMID: 28301629 [PubMed - as supplied by publisher] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - March 12, 2017 Category: Journals (General) Authors: Rodrigues Fernandes LC, Galvão TF, Toledo Ricardi AS, De Capitani EM, Hyslop S, Bucaretchi F Tags: Sao Paulo Med J Source Type: research

Pharmacologic Treatment of Cannabinoid Hyperemesis Syndrome: A Systematic Review
ConclusionHigh‐quality evidence for pharmacologic treatment of CHS is limited. Benzodiazepines, followed by haloperidol and capsaicin, were most frequently reported as effective for acute treatment, and TCAs for long‐term treatment. As the prevalence of CHS increases, future prospective trials are greatly needed to evaluate and further define optimal pharmacologic treatment of patients with CHS.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 1, 2017 Category: Drugs & Pharmacology Authors: John R. Richards, Brent K. Gordon, Aaron R. Danielson, Aimee K. Moulin Tags: Review of Therapeutics Source Type: research

Successful intervention to mitigate an acetylcholinesterase inhibitor ‐induced rhinorrhea prescribing cascade: a case report
We describe an intervention to mitigate a prescribing cascade while continuing a clinically necessary medication without negatively impacting the patient. Case summaryA 77‐year‐old women experienced probable acetylcholinesterase inhibitor‐induced rhinorrhea and subsequently self‐medicated with diphenhydramine which lead to worsening cognitive function. We reduced the dose of the acetylcholinesterase inhibitor and discontinued the diphenhydramine. The symptoms of rhinorrhea were subsequently reduced without negatively impacting cognition. What is new and conclusionThis was the first published prescribing cascade int...
Source: Journal of Clinical Pharmacy and Therapeutics - February 28, 2017 Category: Drugs & Pharmacology Authors: S. M. Vouri, J. M. Chung, E. F. Binder Tags: Case Report Source Type: research

The “Silver Star” Initiative: Proactively Protecting Our Older Adult Population
Topic Significance& Study Purpose/Background/Rationale: BMT recipients aged 65 years or older comprise 30% of patients at this large academic health system. BMT protocols commonly use medications at standardized doses often bringing about the need for aggressive symptom management. Lorazepam, prochlorperazine, promethazine and diphenhydramine are frequently used to treat the nausea, vomiting and diarrhea which often follow BMT conditioning regimens. Literature indicates that geriatric individuals are at a greater risk for medication-related adverse events as described per BEERS and STOP/START criteria. (Source: Biology...
Source: Biology of Blood and Marrow Transplantation - February 22, 2017 Category: Hematology Authors: Jeanne Verrecchio Source Type: research

A phase 2 safety study of accelerated elotuzumab infusion, over less than 1 hour, in combination with lenalidomide and dexamethasone, in patients with multiple myeloma
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 17, 2017 Category: Hematology Authors: James Berenson, Robert Manges, Suprith Badarinath, Alan Cartmell, Kristi McIntyre, Roger Lyons, Wael Harb, Hesham Mohamed, Ali Nourbakhsh, Robert Rifkin Tags: Research Article Source Type: research

Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline
Introduction:The purpose of this guideline is to establish clinical practice recommendations for the pharmacologic treatment of chronic insomnia in adults, when such treatment is clinically indicated. Unlike previous meta-analyses, which focused on broad classes of drugs, this guideline focuses on individual drugs commonly used to treat insomnia. It includes drugs that are FDA-approved for the treatment of insomnia, as well as several drugs commonly used to treat insomnia without an FDA indication for this condition. This guideline should be used in conjunction with other AASM guidelines on the evaluation and treatment of ...
Source: Journal of Clinical Sleep Medicine : JCSM - February 15, 2017 Category: Sleep Medicine Source Type: research

Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data.
Authors: Kanamitsu K, Nozaki Y, Nagaya Y, Sugiyama Y, Kusuhara H Abstract Significant histamine H1 receptor occupation in the central nervous system (CNS) is associated with sedation. Here we examined the time profiles of the H1 receptor occupancy (RO) in the CNS using sedative (diphenhydramine and ketotifen) and non-sedative (bepotastine and olopatadine) antagonists at their therapeutic doses by integrating in vitro and animal data. A pharmacokinetic model was constructed to associate plasma concentrations and receptor binding in the brain. Dissociation and association rate constants with the H1 receptor and ...
Source: Drug Metabolism and Pharmacokinetics - February 14, 2017 Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research

Abstract P3-13-20: Use of a 3-D bioabsorbable tissue marker in 61 patients over two years
Conclusion:The I-SPY 2 adaptive randomization model efficiently evaluates investigational agents in the setting of neoadjuvant BC. The value of I-SPY 2 is that it provides insight as to the regimen's likelihood of success in a phase 3 neoadjuvant study. Although no signature reached the efficacy threshold of 85% likelihood of success in phase 3, we observed the most impact in HR-/HER2- patients, with a 16% improvement in pCR rate. While our data do not support the continued development of Ganetespib alone for neoadjuvant BC, combinations with Ganetespib, which could potentiate its effect, may be worth pursuing in I-SPY 2 o...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: CS Kaufman, W Hall, V Behrndt, G Wolgamot, L Hill, K Zacharias, A Rogers, S Nix, N Schnell Tags: Poster Session Abstracts Source Type: research

Abstract P6-07-22: Association of Hedgehog signaling pathway with luminal B sub-type of breast cancer affected patients of Pakistan
This study evaluated 2 steroid-based mouth rinses for the prevention or amelioration of oral stomatitis in pts with MBC treated with EVE. Methods: This prospective randomized phase II study enrolled postmenopausal pts (planned accrual=100) with HR+ MBC within the US Oncology Network who were initiating therapy with an aromatase inhibitor plus EVE (10 mg/day)(AIE). Pts were randomized 1:1 to prophylactic therapy with 1 of 2 oral rinses (ARM 1: MMW 480 ml recipe: 320 mL oral Benadryl, 2 g Tetracycline, 80 mg Hydrocortisone, 40 mL Nystatin suspension, water; or ARM 2: Prednisolone (P) 15mg/5mL oral solution, 1.8% alcohol). Pt...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: SK Riaz, R Rashid, STA Shah, F Wang, MFA Malik Tags: Poster Session Abstracts Source Type: research

Suppression in Bitterness Intensity of Bitter Basic Drug by Chlorogenic Acid.
This study showed that the bitterness intensity of DPH was suppressed by QNA and CGA through a direct electrostatic interaction with DPH as confirmed in (1)H-NMR spectroscopic analysis. CGA and QNA may therefore be useful bitterness-masking agents for the basic drug DPH. PMID: 28154308 [PubMed - in process] (Source: Chemical and Pharmaceutical Bulletin)
Source: Chemical and Pharmaceutical Bulletin - February 7, 2017 Category: Drugs & Pharmacology Authors: Shiraishi S, Haraguchi T, Nakamura S, Kojima H, Kawasaki I, Yoshida M, Uchida T Tags: Chem Pharm Bull (Tokyo) Source Type: research

Taste-Masking Effect of Chlorogenic Acid (CGA) on Bitter Drugs Evaluated by Taste Sensor and Surface Plasmon Resonance on the Basis of CGA-Drug Interactions.
Abstract The purpose of this study was to evaluate the taste-masking effects of chlorogenic acid (CGA) on bitter drugs using taste sensor measurements and surface plasmon resonance (SPR) analysis of CGA-drug interactions. Six different bitter drugs were used: amlodipine besylate (AMD), diphenhydramine hydrochloride (DPH), donepezil hydrochloride (DNP), rebamipide (RBM), diclofenac sodium (DCF) and etodolac (ETD). Taste sensor outputs were significantly inhibited by the addition of CGA to all drugs. The inhibition ratio of the taste sensor output decreased in the following order DPH>DNP>AMD≈DCF≈RB...
Source: Chemical and Pharmaceutical Bulletin - February 7, 2017 Category: Drugs & Pharmacology Authors: Shiraishi S, Haraguchi T, Nakamura S, Li D, Kojima H, Yoshida M, Uchida T Tags: Chem Pharm Bull (Tokyo) Source Type: research

Face and Neck Swelling Hint at a Daunting Diagnosis
​BY MOHAMMED HASSAN-ALI, MSC, & AHMED RAZIUDDIN, MDA 56-year-old black man presented to the ED complaining of face and neck swelling. An initial history was difficult to obtain because the patient did not speak English fluently and had slurred speech. Symptoms started approximately a week earlier when the patient was at his nursing home. He denied dysphagia or odynophagia, he had no rashes, pruritus, dyspnea, or peripheral edema, his face was flushed, and he had visibly engorged neck veins. He noticed that his tongue was mildly swollen, so he took Benadryl for a week with no relief. The patient said he believed that ...
Source: The Case Files - February 2, 2017 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Intravenous Ferric Carboxymaltose for Iron Deficiency Anemia
Researchers from multiple institutions in Texas conducted a retrospective study of children with iron deficiency anemia (IDA) who received intravenous (IV) ferric carboxymaltose (FCM) at Children’s Medical Center in Dallas. A query of pharmacy records was used to identify study patients who received FCM over a 1-year period. The medical records of study patients were reviewed to assess hematologic response to FCM treatment and adverse events related to therapy. For patients weighing>50 kg, 2 doses (each up to 750 mg) were given at least 7 days apart. Children weighing
Source: AAP Grand Rounds - January 31, 2017 Category: Pediatrics Authors: Hogan, M.-J. S. Tags: Hematology-Oncology Source Type: research

Diphenhydramine for Acute Extrapyramidal Symptoms After Propofol Administration
Extrapyramidal symptoms are an uncommon but well-recognized side effect after the administration of general anesthesia in patients without a significant neurologic history. Several case reports implicate propofol as the likely causative agent producing these symptoms, which include ballismus, dystonia, choreoathetosis, and opisthotonus. Currently, there is no clear consensus on first-line treatment of these symptoms. In each of the published cases, anticholinergic medications and benzodiazepines were central to initial management, although the speed and extent of symptom resolution were variable. Here we present a case of ...
Source: PEDIATRICS - January 31, 2017 Category: Pediatrics Authors: Sherer, J., Salazar, T., Schesing, K. B., McPartland, S., Kornitzer, J. Tags: Neurology, Neurologic Disorders, Anesthesiology/Pain Medicine Case Report Source Type: research

Analysis of Disease Activity Categories in Chronic Spontaneous/Idiopathic Urticaria
ConclusionCategorical UAS7TD disease states can discriminate between measures when considering the impact of urticaria activity. Using five categorical disease states could simplify clinical assessment and monitoring of treatment efficacy.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - January 31, 2017 Category: Dermatology Authors: D. Stull, D. McBride, H. Tian, A. Gimenez Arnau, M. Maurer, A.  Marsland, M.‐M. Balp, S. Khalil, C. Grattan Tags: Original Article Source Type: research

Continued midazolam versus diphenhydramine in difficult-to-sedate patients: a randomized double-blind trial
Current guidelines recommend diphenhydramine in patients undergoing endoscopy who are not adequately sedated with a benzodiazepine and opioid combination. Because this practice has not been adequately assessed, we performed a randomized, double-blind trial comparing diphenhydramine to continued midazolam in such patients. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - January 30, 2017 Category: Gastroenterology Authors: Hamita Sachar, Nipaporn Pichetshote, Kavitha Nandigam, Keta Vaidya, Loren Laine Source Type: research

Machine learning-based prediction of adverse drug effects: an example of seizure-inducing compounds
Publication date: Available online 28 January 2017 Source:Journal of Pharmacological Sciences Author(s): Mengxuan Gao, Hideyoshi Igata, Aoi Takeuchi, Kaoru Sato, Yuji Ikegaya Various biological factors have been implicated in convulsive seizures, involving side effects of drugs. For the preclinical safety assessment of drug development, it is difficult to predict seizure-inducing side effects. Here, we introduced a machine learning-based in vitro system designed to detect seizure-inducing side effects. We recorded local field potentials from the CA1 alveus in acute mouse neocortico-hippocampal slices, while 14 drugs were ...
Source: Journal of Pharmacological Sciences - January 28, 2017 Category: Drugs & Pharmacology Source Type: research

New Treatment for Soft Tissue Sarcoma
* Olaratumab (Lartruvo) is the first new drug approved in more than 40 years for the treatment of soft tissue sarcoma. It is administered as an IV infusion in combination with doxorubicin. * There is a risk of serious infusion-related reactions with olaratumab use. Grade 3 or 4 reactions require that the infusion be stopped immediately and not restarted. Embryo-fetal toxicity can occur if olaratumab is given to pregnant women. * Nurses should premedicate patients with diphenhydramine and dexamethasone prior to the first dose of olaratumab to help minimize the risk of infusion reactions. Patients require close monitorin...
Source: AJN - January 27, 2017 Category: Nursing Tags: Drug Watch Source Type: research

Inhibitory effects of antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells.
We examined the effects of the H1 antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells recorded using the whole-cell patch clamp technique. Diphenhydramine and chlorpheniramine reduced the proton currents with almost the same potency, yielding IC50 values of 42 and 43μM, respectively. Histamine did not affect proton currents, excluding the involvement of histamine receptors in their action. Neither drug shifted the voltage-dependence of activation or the reversal potential of the proton currents, even though diphenhydramine slowed the activation and deactivation kinetics. The ...
Source: European Journal of Pharmacology - January 24, 2017 Category: Drugs & Pharmacology Authors: Kim J, Song JH Tags: Eur J Pharmacol Source Type: research

Diphenhydramine as a cause of visual hallucinations in older adults
(Source: Geriatrics and Gerontology International)
Source: Geriatrics and Gerontology International - January 22, 2017 Category: Geriatrics Authors: Supakanya Wongrakpanich, Marvin Louis Roy Lu, Andrew Rosenzweig Tags: CASE REPORT Source Type: research

pH/thermo-responsive poly(N-isopropylacrylamide-co-maleic acid) hydrogel with a sensor and an actuator for biomedical applications
Publication date: 10 February 2017 Source:Polymer, Volume 110 Author(s): Gheorghe Fundueanu, Marieta Constantin, Sanda Bucatariu, Paolo Ascenzi Poly(N-isopropylacrylamide-co-maleic acid) (poly(NIPAAm-co-MAc)) with an appropriate comonomer ratio was designed and synthesized as an appealing pH/thermo-responsive copolymer. In simulated physiological fluids (phosphate buffer solution (PBS) at pH = 7.4 and T = 36 °C), both carboxylic groups of MAc in copolymer (pKa1 = 3.45, pKa2 = 6.09) are in the ionized form, more hydrophilic and consequently the copolymer loses the thermosens...
Source: Polymer - January 16, 2017 Category: Chemistry Source Type: research

Rococo study: a real-world evaluation of an over-the-counter medicine in acute cough (a multicentre, randomised, controlled study)
Objectives To investigate the efficacy and safety of CS1002, an over-the-counter cough treatment containing diphenhydramine, ammonium chloride and levomenthol in a cocoa-based demulcent. Design A multicentre, randomised, parallel group, controlled, single-blinded study in participants with acute upper respiratory tract infection-associated cough. Setting 4 general practitioner (GP) surgeries and 14 pharmacies in the UK. Participants Participants aged ≥18 years who self-referred to a GP or pharmacist with acute cough of
Source: BMJ Open - January 15, 2017 Category: Journals (General) Authors: Birring, S. S., Brew, J., Kilbourn, A., Edwards, V., Wilson, R., Morice, A. H. Tags: Open access, General practice / Family practice, Respiratory medicine Research Source Type: research

Life-threatening simultaneous acute stent thrombosis associated with anaphylactic shock due to contrast material
A 66-year-old man with acute coronary syndrome (ACS) underwent emergent percutaneous coronary intervention (PCI) with implantation of two everolimus-eluting stents (EES) for severe stenosis in the proximal and distal right coronary artery (RCA) (PanelsA and B). At 1 week, after EES implantation, we performed staged PCI for the stenotic lesion in mid left circumflex artery (LCx) (Panel E). After injection of contrast material into left coronary artery, blood pressure was 58/38 mmHg and the pulse rate 112 beats/min. He had an erythematous rash over all the body and complained of chest discomfort. Immediately, he was d...
Source: European Heart Journal - January 9, 2017 Category: Cardiology Source Type: research

Hot and Cold Drugs: National Park Service Medication Stability at the Extremes of Temperature.
CONCLUSIONS: We recommend that EMS providers replace atropine, naloxone, diphenhydramine, fentanyl, and midazolam frequently if they are practicing in low call volume or high-temperature environments. Further studies will be needed to determine if re-dosing midazolam, naloxone, and atropine is the appropriate clinical strategy in this setting if adequate clinical effect is not reached with a single dose. PMID: 28059581 [PubMed - as supplied by publisher] (Source: Prehospital Emergency Care)
Source: Prehospital Emergency Care - January 7, 2017 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Randomized Trial of Adding Parenteral Acetaminophen to Prochlorperazine and Diphenhydramine to Treat Headache in the Emergency Department. Meyering, Stefan H; Stringer, Ryan W; Hysell, Matthew K
Abstract Introduction: Headaches represent over 3 million Emergency Department visits per year comprising 2.4 percent of all ED visits. Headaches are thought to be one of the three most common complaints of patient presentations to EDs across the country. There are many proposed methods and clinical guidelines of treating acute headache presentations however data on intravenous acetaminophen usage in these settings are lacking.   Objectives: The study attempts to determine the efficacy of IV Acetaminophen as an adjunct to a standard therapy for the treatment of patients who present to the emergency d...
Source: Western Journal of Emergency Medicine - January 1, 2017 Category: Emergency Medicine Source Type: research

Combination of ofatumumab and reduced-dose CHOP for diffuse large B-cell lymphomas in patients aged 80 years or older: an open-label, multicentre, single-arm, phase 2 trial from the LYSA group
This study was registered with ClinicalTrials.gov, number NCT01195714. Findings Between June 2, 2010, and Nov 4, 2011, we enrolled 120 patients. Age-adjusted International Prognostic Index was 2–3 in 68 (57%) of them. The median follow-up time was 26·8 months (IQR 24·5–30·1). The 2-year overall survival was 64·7% (95% CI 55·3–72·7) and median overall survival was not reached (95% CI 30·2–not reached). 45 patients died during the treatment, of whom 28 (62%) died due to lymphoma. The most common side-effect was haematological toxicity. Among the 120 pat...
Source: The Lancet Haematology - December 29, 2016 Category: Hematology Source Type: research

Premedication Use Before Infliximab Administration: A Cross-sectional Analysis
Conclusions: There is high interpractice and intrapractice variability for premedication use before infliximab administration. Clinician rationale for premedicating patients seems to be driven by individual preference or group practice habit. Improved knowledge of the evidence may assist in decreasing overuse of premedications, particularly diphenhydramine. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - December 24, 2016 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research

Knowledge and Attitude Towards Pharmacological Management of Acute Agitation: A Survey of Psychiatrists, Psychiatry Residents, and Psychiatric Nurses.
CONCLUSION: Knowledge of evidence-based psychopharmacological management of agitation differs among attending psychiatrists, psychiatry residents and psychiatric nurses. Although the management of agitation should be individualized and context specific, monotherapy should be considered first where applicable. PMID: 27943131 [PubMed - as supplied by publisher] (Source: The Journal of American Association of Directors of Psychiatric Residency Training)
Source: The Journal of American Association of Directors of Psychiatric Residency Training - December 15, 2016 Category: Psychiatry Tags: Acad Psychiatry Source Type: research

Knowledge and Attitude Towards Pharmacological Management of Acute Agitation: A Survey of Psychiatrists, Psychiatry Residents, and Psychiatric Nurses
ConclusionKnowledge of evidence-based psychopharmacological management of agitation differs among attending psychiatrists, psychiatry residents and psychiatric nurses. Although the management of agitation should be individualized and context specific, monotherapy should be considered first where applicable. (Source: Academic Psychiatry)
Source: Academic Psychiatry - December 8, 2016 Category: Psychiatry Source Type: research

Pharmacodynamic response profiles of anxiolytic and sedative drugs
ConclusionsCompared with the antihistaminergic sedative diphenhydramine, alprazolam and pregabalin caused larger SPV‐reduction, which was correlated with simultaneous improvement of subjective calmness, during a study day in which anxiety was stimulated repeatedly. The different effect profiles of the three drugs are in line with their pharmacological distinctions. These findings corroborate the profiling of CNS effects to demonstrate pharmacological selectivity, and further support SPV as biomarker for anxiolysis involving GABA‐ergic neurons. The study also supports the use of prolonged mild threat to demonstrate anxi...
Source: British Journal of Clinical Pharmacology - November 30, 2016 Category: Drugs & Pharmacology Authors: Xia Chen, Freerk Broeyer, Marieke Kam, Joke Baas, Adam Cohen, Joop Gerven Tags: CLINICAL TRIALS Source Type: research

Regenerated cellulose capsules for controlled drug delivery: Part IV. In-vitro evaluation of novel self-pore forming regenerated cellulose capsules.
Abstract In the present work, the release mechanisms of active pharmaceutical ingredients (APIs) enclosed in self-pore forming regenerated cellulose (RC) two-piece hard shell capsules are described. The RC capsules were fabricated using a modified dip-coating approach, which yielded an assembled dosage form that was equivalent in size and shape to a conventional gelatin two-piece hard shell capsule. Drug release characteristics from RC capsules were evaluated using potassium chloride, diphenhydramine hydrochloride, tramadol hydrochloride, niacinamide, acetaminophen and ketoprofen as model APIs. The RC capsules act...
Source: European Journal of Pharmaceutical Sciences - November 30, 2016 Category: Drugs & Pharmacology Authors: Bhatt B, Kumar V Tags: Eur J Pharm Sci Source Type: research

Refractory Cutaneous IgA Vasculitis Treated with Omega-3 Fatty Acids
Conclusions: O3FA can be useful to control cutaneous IgAV.Case Rep Dermatol 2016;8:333 –340 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - November 29, 2016 Category: Dermatology Source Type: research

Presence of an H + /Quinidine Antiport System in Madin –Darby Canine Kidney Cells
ConclusionsThe present findings suggested that the renal new antiport system is involved in the bidirectional membrane transport of quinidine in MDCK cells. (Source: European Journal of Drug Metabolism and Pharmacokinetics)
Source: European Journal of Drug Metabolism and Pharmacokinetics - November 25, 2016 Category: Drugs & Pharmacology Source Type: research

A multi-omic approach to elucidate low-dose effects of xenobiotics in zebrafish (Danio rerio) larvae
Publication date: Available online 18 November 2016 Source:Aquatic Toxicology Author(s): Susie S.Y. Huang, Jonathan P. Benskin, Nik Veldhoen, Bharat Chandramouli, Heather Butler, Caren C. Helbing, John R. Cosgrove Regulatory-approved toxicity assays such as the OECD Fish Embryo Toxicity Assay (TG236) allow correlation of chemical exposure to adverse morphological phenotypes. However, these assays are ineffective in assessing sub-lethal (i.e. low-dose) effects, or differentiating between similar phenotypes induced by different chemicals. Inclusion of multi-omic analyses in studies investigating xenobiotic action provides i...
Source: Aquatic Toxicology - November 17, 2016 Category: Toxicology Source Type: research