Fight Aging! Newsletter, July 17th 2017
This study aimed to estimate associations between combined measurements of BMI and waist-to-hip ratio (WHR) with mortality and incident coronary artery disease (CAD). This study followed 130,473 UK Biobank participants aged 60-69 years (baseline 2006-2010) for 8.3 years (n = 2974 deaths). Current smokers and individuals with recent or disease-associated (e.g., from dementia, heart failure, or cancer) weight loss were excluded, yielding a "healthier agers" group.
Ignoring WHR, the risk of mortality for overweight subjects was similar to that for normal-weight subjects. However, among normal-weight subjects, mortalit...
Source: Fight Aging! - July 16, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards the Mass Manufacture of Blood Platelets
Blood donation will at some point in the next decade or two be replaced with the mass manufacture of blood, produced to order and as needed. It will be far more efficient than the present system of donations and stockpiles, but there is still a great deal of work to be accomplished in order to reach this goal. The review here covers just a fraction of the scope of work, focused on the technical details of the production of platelets and their predecessor cells. Currently this is being carried out somewhat in advance of any ability to scale up to a far larger pace of production, but that will come with time. As the paper sh...
Source: Fight Aging! - July 11, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Von Willebrand ’s Disease via Now@NEJM
Von Willebrand's Disease via Now@NEJMPosted oninfosnack. (Source: Kidney Notes)
Source: Kidney Notes - November 23, 2016 Category: Urology & Nephrology Authors: Joshua Schwimmer Source Type: blogs
Heyde ’ s syndrome: Acquired von Willebrand Syndrome in Severe Aortic Stenosis
Severe gastrointestinal bleeding can occur in those with severe aortic stenosis (Heyde’s syndrome). The initial description was in 1958 [1]. An important mechanism for the bleeding is deficiency of large von Willebrand factor multimers. This is due to the structural damage to the large protein when blood passes through the severely stenotic aortic valve as a high velocity jet. Loss of large multimers can be measured as the large von Willebrand factor multimer index and it is significant if it is less than 80% [2]. Anemia due to Heyde’s syndrome improves after aortic valve replacement. The gastro intestinal blee...
Source: Cardiophile MD - August 1, 2016 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology Source Type: blogs
Improved Synthetic Blood Platelets Spur Clotting
Present work on artificial blood tends to focus on narrow areas of functionality in which short-term augmentation of the capabilities of natural blood are useful, such as oxygen transport and clotting. From these diverse paths a wholly artificial blood substitute will no doubt eventually arise, but bear in mind that this line of development faces stiff competition from the use of cell technologies to produce biological blood as needed. One way or another blood donation will be a thing of the past not so many years from now:
An additive nanoparticle manufacturing process has been used to design and realize a synthetic plat...
Source: Fight Aging! - November 10, 2014 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Research and Reviews in the Fastlane 052
This study looked at compliance with discharge instructions. Surprisingly (or maybe not so), 39% of pediatric patients returned to play (RTP) on the day of the injury. RTP is widely recognized as a risk for recurrent and more severe concussions as well as significant morbidity. It is the duty of the Emergency Physician to stress the importance of discharge instructions as well as the importance of appropriate follow up.
Recommended by: Anand Swaminathan
PediatricsSingleton T et al. Emergency department care for patients with hemophilia and von Willebrand disease. J Emerg Med. 2010; 39(2): 158-65. PMID: 18757163
Bleeding...
Source: Life in the Fast Lane - October 9, 2014 Category: Emergency Medicine Authors: Nudrat Rashid Tags: Administration Anaesthetics Cardiology Clinical Research Education Emergency Medicine Haematology Infectious Disease Intensive Care International Emergency Medicine Microbiology Neurosurgery Obstetrics / Gynecology Ophthalmology Source Type: blogs
The LITFL Review 148
The LITFL Review is your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chuck of FOAM.
Welcome to the 148th edition, brought to you by:
Anand Swaminathan [AS] (EM Lyceum, iTeachEM)
Brent Thoma [BT] (BoringEM and Academic Life in EM)
Chris Connolly [CC]
Chris Nickson [CN] ( iTeachEM, RAGE, INTENSIVE and SMACC)
Joe-Anthony Rotella [JAR]
Kane Guthrie [KG]
Mat Goebel [MG]
Segun Olusany...
Source: Life in the Fast Lane - August 12, 2014 Category: Emergency Medicine Authors: Kane Guthrie Tags: LITFL review LITFL R/V Source Type: blogs
Research and Reviews in the Fastlane 041
This study prospectively validated whether an age-adjusted D-dimer cutoff was associated with an increased diagnostic yield of D-dimer in elderly patients with suspected PE. Compared with a fixed D-dimer cutoff, the combination of pretest clinical probability assessment with age-adjusted D-dimer cutoff was associated with a larger number of patients in whom PE could be considered ruled out with a low likelihood of subsequent clinical venous thromboembolism. So if this is not your clinical practice already, maybe time to use age adjust d-dimer values?
Recommended by: Jerremy Fried
Read More: Age Adjusted D-Dimer Testing (RE...
Source: Life in the Fast Lane - July 29, 2014 Category: Emergency Medicine Authors: Soren Rudolph Tags: Clinical Research R&R in the FASTLANE critical care Emergency Medicine Intensive Care literature recommendations research and reviews Source Type: blogs
Phenocopy Mimics of Rare Diseases: Lessons for the Common Diseases
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. The topic of phenocopy diseases was introduced in yesterday's blog post. Phenocopy diseases are medical conditions that closely mimic a genetic disease, but are caused or triggered by an environmental factor. In many cases, phenocopy diseases are non-hereditary and acute. In some cases, the phenocopy disease is reversible when the environmental ...
Source: Specified Life - July 6, 2014 Category: Pathologists Tags: common disease complex disease disease biology genetic disease mimics of disease orphan disease orphan drugs pathogenesis phenocopy disease principles of pathology rare disease Source Type: blogs
Baxter completes patient enrollment in phase III trial of BAX 855, extended half-life rFVIII to treat haemophilia A
Baxter International Inc. has completed enrollment in its phase III clinical trial of BAX 855, an investigational extended half-life, recombinant factor VIII (rFVIII) treatment for haemophilia A. The ongoing trial is aimed at assessing the efficacy of the compound in reducing annualized bleed rates (ABR) in both prophylaxis and on-demand treatment schedules, and will also evaluate its safety and pharmacokinetic profile.BAX 855 was designed based on the full-length ADVATE [Antihemophilic Factor (Recombinant) Plasma/Albumin-Free Method] molecule, a product with 10 years of real-world experience. The BAX 855 molecule was modi...
Source: Medical Hemostat - November 15, 2013 Category: Technology Consultants Authors: hemostatguy at gmail.com (hemostat guy) Source Type: blogs
Treatment of salivary gland hypofunction by transplantation with dental pulp cells
ConclusionsOur results show that radiation-induced salivary hypofunction is partially reverted following transplantation of DPECs. We established a mouse model in which DPCs could be used as a cell source for the treatment of salivary gland hypofunction. (Source: Dental Technology Blog)
Source: Dental Technology Blog - June 29, 2013 Category: Dentists Source Type: blogs
NIH - NHLBI Discontinues Guidelines Program Passes Work off to Associations
Conclusion
NHLBI's decision demonstrates an interesting point: even the most cutting edge scientists who are constantly analyzing new scientific and medical information and data are sometimes not able to keep up with the pace or have enough resources to synthesize this kind of information to create new information that physicians can act on to improve patient care. This point is the very heart of why continuing medical education (CME) is so critical for America's healthcare system.
CME provides an additional resource for physicians who do not have the time or resources to learn about clinical practice guidelines, t...
Source: Policy and Medicine - June 20, 2013 Category: Health Medicine and Bioethics Commentators Authors: Thomas Sullivan Source Type: blogs
FDA: Enhancing Benefit-Risk Assessment in Regulatory Decision Making
Last summer, Congress enacted the Food and Drug Administration Safety and Innovation Act (FDASIA), which included the fifth authorization of the Prescription Drug User Fee Act (PDUFA V). Title I of FDASIA reauthorizes the Prescription Drug User Fee Act (PDUFA), which provides FDA with the necessary user fee resources to maintain an efficient review process for human drug and biologic products. The reauthorization of PDUFA includes performance goals and procedures that represent FDA’s commitments during FY 2013-2017. These commitments are referred to in section 101 of FDASIA.
Section X of these commitments relates ...
Source: Policy and Medicine - April 25, 2013 Category: Health Medicine and Bioethics Commentators Authors: Thomas Sullivan Source Type: blogs
