What's new in midwifery - research evidence - 12th April 2023
Recent research articles that might be useful to know about.Infant feeding method and special educational need, a cohort study of 191745 Scottish schoolchildren.von Willebrand disease in pregnancy.Another systematic review of COVID vaccination in pregnancy, abstract and link in McMaster ' s Evidence Alerts. Postpartum hypertension, abstract and link in McMaster ' s Evidence Alerts.Safety and immunogenicity of an RSV vaccine in mothers and their infants.Intravenous ketorolac after cesarean, link and abstract in McMaster ' s Evidence Alerts. Induction of labour at or near term for suspected fetal macrosomia - Cochr...
Source: Browsing - April 12, 2023 Category: Databases & Libraries Tags: midwifery Source Type: blogs
Airway hemorrhage in Eisenmenger syndrome
In Eisenmenger syndrome airway hemorrhages have to be thought of specially when moving from lower to a higher altitude as during air travel or while ascending a mountain. Hemoptysis has been reported as a cause of death in Eisenmenger syndrome in 11-29% [1].
Defects in hemostatic mechanism due to abnormal platelet function, thrombocytopenia, deficiencies of clotting factor as well as depletion of von Willebrand factor may also contribute to airway hemorrhages in Eisenmenger syndrome [2].
References
Jensen AS, Iversen K, Vejlstrup NG, Sondergaard L. Pulmonary artery thrombosis and hemoptysis in Eisenmenger syndrome. ...
Source: Cardiophile MD - November 20, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Fight Aging! Newsletter, December 20th 2021
In conclusion, the low dose, prolonged angiotensin II exposure is associated with the induction of senescence in kidneys and the promotion of an inflammatory microenvironment through both secreted factors and immune cells. Endothelial cells appear to be a major cell type impacted. The elimination of senescent cells in the INK-ATTAC transgenic model prevents these effects of angiotensin II and reveals a novel pathophysiologic mechanism amenable to targeting by senolytic drugs in development.
CYTOR Upregulation as a Path to Improved Muscle Function in Later Life
https://www.fightaging.org/archives/2021/12/cytor-...
Source: Fight Aging! - December 19, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Cells Mediate the Harmful Effects of Angiotensin II
In conclusion, the low dose, prolonged angiotensin II exposure is associated with the induction of senescence in kidneys and the promotion of an inflammatory microenvironment through both secreted factors and immune cells. Endothelial cells appear to be a major cell type impacted. The elimination of senescent cells in the INK-ATTAC transgenic model prevents these effects of angiotensin II and reveals a novel pathophysiologic mechanism amenable to targeting by senolytic drugs in development.
Link: https://doi.org/10.3389/fcell.2021.782841 (Source: Fight Aging!)
Source: Fight Aging! - December 15, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The syndrome of vanishing ACS : Who activates spontaneous thrombolysis ?
Background
“Your husband was really lucky, his heart attack got spontaneously aborted. His ECG is near normal now. The angiogram is normal.No stent, no lysis. He secreted his own Tpa and got rid of the clot. We will discharge him to tomorrow.”
Thank you very much, Doctor. How did this happen, doctor?
Don’t thank me. Definitely, I don’t have an answer. Spontaneous successful thrombolysis (Ref 4) happens up to 15 % of ACS. All I can say is he has a very disciplined mast cell network and fibrinolytic system.
Vascular events: Pathobiology
Vascular highway accidents that happen due to the sudden fr...
Source: Dr.S.Venkatesan MD - October 8, 2021 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized anti fibrinolytic system thrombolysis Source Type: blogs
The syndrome of vanishing ACS : Who activates spontaneous thrombolysis doctor ?
Background
“Your husband was really lucky, his heart attack got spontaneously aborted. His ECG is near normal now. The angiogram is normal.No stent, no lysis. He secreted his own Tpa and got rid of the clot. We will discharge him to tomorrow.”
Thank you very much, Doctor. How did this happen, doctor?
Don’t thank me. Definitely, I don’t have an answer. Spontaneous successful thrombolysis (Ref 4) happens up to 15 % of ACS. All I can say is he has a very disciplined mast cell network and fibrinolytic system.
Vascular events: Pathobiology
Vascular highway accidents that happen with sudden freezing...
Source: Dr.S.Venkatesan MD - October 8, 2021 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized anti fibrinolytic system thrombolysis Source Type: blogs
When is a heavy period too heavy?
It’s common for girls and their parents to wonder if the bleeding with their periods is too often or too much. Especially in the first few years of having a period, any bleeding can feel like too much. Usually, it’s not — but sometimes it is, and it’s important for parents to know what to watch for, and when to call the doctor.
In the first couple of years after periods begin, it’s really normal for periods to be irregular — and for some of them to be heavy. At the beginning, periods aren’t associated with ovulation, and the hormones and hormonal patterns that help regulate periods haven’t fallen into place...
Source: Harvard Health Blog - February 12, 2020 Category: Consumer Health News Authors: Claire McCarthy, MD Tags: Adolescent health Children's Health Parenting Source Type: blogs
Fight Aging! Newsletter, April 29th 2019
In this study, we report the age-associated differences between fetal MSC (fMSC) populations and MSCs isolated from elderly donors with respect to their transcriptomes. We successfully reprogrammed fMSCs (55 days post conception) and adult MSC (aMSC; 60-74 years) to iPSCs and, subsequently, generated the corresponding iMSCs. In addition, iMSCs were also derived from ESCs. The iMSCs were similar although not identical to primary MSCs. We unraveled a putative rejuvenation and aging gene expression signature. We show that iMSCs irrespective of donor age and cell type re-acquired a similar secretome to that of their parent...
Source: Fight Aging! - April 28, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Dysfunctional and Senescent Immune Cells in Bone Marrow as a Cause of Age-Associated Lineage Skewing of Hematopoietic Stem Cells
The immune system declines with age for a range of reasons. The thymus atrophies, reducing the supply of new T cells; persistent infection by cytomegalovirus causes cells to become uselessly specialized rather than ready to tackle new threats; and the hematopoietic stem cells responsible for generating immune cells become damaged, inactive, and dysfunctional. One of these forms of dysfunction is that hematopoietic stem cells begin to generate too many myeloid cells and too few lymphoid cells, the so-called myeloid skew.
The cause of this skewing in cell production is much debated, but researchers have found that chr...
Source: Fight Aging! - April 26, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
GI bleed with Continuous flow LVAD – Mechanisms
GI bleed with Continuous flow LVAD – Mechanisms
Gastrointestinal bleeds can occur in 15-40% of patients on continuous flow left ventricular assist devices (LVAD) for end stage heart failure. Proposed mechanisms for gastrointestinal bleeds with continuous flow LVAD includes:
Acquired von Willebrand disease
Impaired platelet aggregation
Enhanced angiogenesis causing arteriovenous malformations (AVM)
Intensity of anticoagulation
AVMs may contribute to about half of the GI bleed with continuous flow LVADS. Hypoperfusion of gastrointestinal mucosa leads to angiogenesis and the new friable vessels are prone for bleeding...
Source: Cardiophile MD - April 13, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiac Surgery Source Type: blogs
New Treatment for Acquired Thrombotic Thrombocytopenic Purpura: Caplacizumab
Immune-mediated deficiency of the von Willebrand factor –cleaving protease ADAMTS13 allows unrestrained adhesion of von Willebrand factor multimers to platelets and microthrombosis. This results in thrombocytopenia, hemolytic anemia, and tissue ischemia. These are the hallmarks of acquired thrombotic thrombocytopenic purpura (TTP).Caplacizumab is an anti –von Willebrand factor humanized. Caplacizumab is not a full antibody, but just a fragment if it, as you can see in the video below. It inhibits interaction between von Willebrand factor multimers and platelets.In this double-blind, controlled trial, 145 patients...
Source: Clinical Cases and Images - Blog - February 1, 2019 Category: Universities & Medical Training Tags: Hematology NEJM Source Type: blogs
TXA a Late Bloomer in Bleeding Management
Tranexamic acid (TXA) was invented by a Japanese husband-and-wife research team in the 1960s. Years earlier, this same research team had discovered epsilon-aminocaproic acid, a derivative and an analogue of the amino acid lysine. In their search for a more potent antifibrinolytic agent, they discovered tranexamic acid, a synthetic analog of the amino acid lysine. Tranexamic acid is eight to 10 times more powerful than epsilon-aminocaproic acid.The antifibrinolytic actions of TXA result from the binding of four or five lysine receptor sites on plasminogen. This binding prevents plasmin from binding to and degrading fibri...
Source: M2E Too! Mellick's Multimedia EduBlog - February 1, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
TAVR reverses the acquired Von Willebrand syndrome in severe aortic stenosis
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - October 7, 2018 Category: Internal Medicine Tags: cardiovascular hematology Source Type: blogs
Acquired von Willebrand disease in severe aortic stenosis: reversal with TAVR
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - May 23, 2018 Category: Internal Medicine Tags: cardiovascular hematology Source Type: blogs
Airway hemorrhage in Eisenmenger syndrome – Cardiology MCQ – Answer
New !!!
Cardiology MCQs from Cardiophile MD – Volume 3: Interactive Kindle Edition
Cardiology MCQs from Cardiophile MD – Volume 3 Paperback
All of the following are true about airway hemorrhages in Eisenmenger syndrome except:
Correct answer: c) More likely while descending a mountain
In Eisenmenger syndrome airway hemorrhages have to be thought of specially when moving from lower to a higher altitude as during air travel or while ascending a mountain. Hemoptysis has been reported as a cause of death in Eisenmenger syndrome in 11-29% [1].
Defects in hemostatic mechanism due to abnormal platelet function, throm...
Source: Cardiophile MD - May 15, 2018 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
