Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model by Reducing the Expression of Pdpn
ConclusionsInhibiting the expression ofMMP13 could reduce the burden of DVT in mice. The mechanism involves downregulating the expression ofPdpn throughMMP13, which could provide a novel gene target for DVT diagnosis and treatment. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - April 15, 2024 Category: Research Source Type: research
The Proteasome Inhibitor Carfilzomib exerts anti-inflammatory and anti-thrombotic effects on the endothelium
CONCLUSION(S): This data demonstrates that CFZ is unable to induce ER stress in confluent resting endothelial cells and can conversely attenuate the pro-thrombotic effects of TNFα on the endothelium. This study suggests that CFZ does not negatively alter HUVECs, and proteasome inhibition of the endothelium may offer a potential way to prevent thrombosis.PMID:38608731 | DOI:10.1016/j.jtha.2024.03.024 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 12, 2024 Category: Hematology Authors: Ahmed Hjazi Celia Gonzalez Maroto Michael Appiah Maria Elena Rodriguez-Gutierrez Ana Ignat Golzar Mobayen Theresa Page Thomas A J McKinnon Source Type: research
Small intestinal angiodysplasia and hemorrhage associated with acquired von Willebrand syndrome type 2A secondary to multiple myeloma: Reversal after treatment with IRD regimen (a case report and a brief review of the literature)
Acquired von Willebrand syndrome (AVWS) is a rare acquired hemorrhagic disorder, characterized by qualitative or quantitative deficiencies in von Willebrand factor (VWF), which is easily misdiagnosed as a genetic von Willebrand disease (VWD) and probably underdiagnosed [1,2]. Usually, the diagnosis of AVWS is complicated, and both clinical and case history evaluation as well as laboratory results are required for discerning AVWS from inherited VWD [2,3]. Here we report a case of AVWS secondary to IgA-kappa type of multiple myeloma (MM), found that the existence of anti-VWF autoantibodies (IgG type) in plasma may contribute...
Source: Thrombosis Research - April 11, 2024 Category: Hematology Authors: Yuxin Zhang, Xuquan Zhou, Yujie Guo, Yongning Gao, Zhiyun Niu, Yi Wu, Yan Wang, Jingyu Zhang Tags: Letter to the Editors-in-Chief Source Type: research
Factor VIII and von Willebrand factor are wavering proteins: the basis for the therapeutic development of desmopressin
Res Pract Thromb Haemost. 2024 Mar 15;8(2):102369. doi: 10.1016/j.rpth.2024.102369. eCollection 2024 Feb.NO ABSTRACTPMID:38595335 | PMC:PMC11002306 | DOI:10.1016/j.rpth.2024.102369 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 10, 2024 Category: Hematology Authors: Pier Mannuccio Mannucci Simona Maria Siboni Source Type: research
Factor VIII and von Willebrand factor are wavering proteins: the basis for the therapeutic development of desmopressin
Res Pract Thromb Haemost. 2024 Mar 15;8(2):102369. doi: 10.1016/j.rpth.2024.102369. eCollection 2024 Feb.NO ABSTRACTPMID:38595335 | PMC:PMC11002306 | DOI:10.1016/j.rpth.2024.102369 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 10, 2024 Category: Hematology Authors: Pier Mannuccio Mannucci Simona Maria Siboni Source Type: research
Ultrasound in addition to clinical assessment of acute musculoskeletal complaints in bleeding disorders: impact on patient management
CONCLUSION: Ultrasound in addition to clinical assessment of acute musculoskeletal complaints in people with hemophilia and VWD has an impact on diagnosis (36%) and treatment (39%), which supports the use of ultrasound in acute musculoskeletal complaints in hemophilia and VWD.PMID:38590365 | PMC:PMC10999475 | DOI:10.1016/j.rpth.2024.102372 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 9, 2024 Category: Hematology Authors: Flora Hendrica Pieternella van Leeuwen Wouter Foppen Pim A de Jong Wobke E M van Dijk Johan Blokzijl Kathelijn Fischer Merel A Timmer Source Type: research
A continuum model for the elongation and orientation of Von Willebrand factor with applications in arterial flow
We present a novel continuum model for VWF dynamics in flow based on a modified viscoelastic fluid model that incorporates a single constitutive relation to describe the propensity of VWF to unfold as a function of the scalar shear rate. Using experimental data of VWF unfolding in pure shear flow, we fix the parameters for VWF's unfolding propensity and the maximum VWF length, so that the protein is half unfolded at a shear rate of approximately 5000 s - 1 . We then use the theoretical model to predict VWF's behaviour in two complex flows where experimental data are challenging to obtain: pure elongational flow and ste...
Source: Biomechanics and Modeling in Mechanobiology - April 9, 2024 Category: Biomedical Science Authors: E F Yeo J M Oliver N Korin S L Waters Source Type: research
Ultrasound in addition to clinical assessment of acute musculoskeletal complaints in bleeding disorders: impact on patient management
CONCLUSION: Ultrasound in addition to clinical assessment of acute musculoskeletal complaints in people with hemophilia and VWD has an impact on diagnosis (36%) and treatment (39%), which supports the use of ultrasound in acute musculoskeletal complaints in hemophilia and VWD.PMID:38590365 | PMC:PMC10999475 | DOI:10.1016/j.rpth.2024.102372 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 9, 2024 Category: Hematology Authors: Flora Hendrica Pieternella van Leeuwen Wouter Foppen Pim A de Jong Wobke E M van Dijk Johan Blokzijl Kathelijn Fischer Merel A Timmer Source Type: research
A continuum model for the elongation and orientation of Von Willebrand factor with applications in arterial flow
We present a novel continuum model for VWF dynamics in flow based on a modified viscoelastic fluid model that incorporates a single constitutive relation to describe the propensity of VWF to unfold as a function of the scalar shear rate. Using experimental data of VWF unfolding in pure shear flow, we fix the parameters for VWF's unfolding propensity and the maximum VWF length, so that the protein is half unfolded at a shear rate of approximately 5000 s - 1 . We then use the theoretical model to predict VWF's behaviour in two complex flows where experimental data are challenging to obtain: pure elongational flow and ste...
Source: Biomechanics and Modeling in Mechanobiology - April 9, 2024 Category: Biomedical Science Authors: E F Yeo J M Oliver N Korin S L Waters Source Type: research
A continuum model for the elongation and orientation of Von Willebrand factor with applications in arterial flow
We present a novel continuum model for VWF dynamics in flow based on a modified viscoelastic fluid model that incorporates a single constitutive relation to describe the propensity of VWF to unfold as a function of the scalar shear rate. Using experimental data of VWF unfolding in pure shear flow, we fix the parameters for VWF's unfolding propensity and the maximum VWF length, so that the protein is half unfolded at a shear rate of approximately 5000 s - 1 . We then use the theoretical model to predict VWF's behaviour in two complex flows where experimental data are challenging to obtain: pure elongational flow and ste...
Source: Biomechanics and Modeling in Mechanobiology - April 9, 2024 Category: Biomedical Science Authors: E F Yeo J M Oliver N Korin S L Waters Source Type: research
A continuum model for the elongation and orientation of Von Willebrand factor with applications in arterial flow
We present a novel continuum model for VWF dynamics in flow based on a modified viscoelastic fluid model that incorporates a single constitutive relation to describe the propensity of VWF to unfold as a function of the scalar shear rate. Using experimental data of VWF unfolding in pure shear flow, we fix the parameters for VWF's unfolding propensity and the maximum VWF length, so that the protein is half unfolded at a shear rate of approximately 5000 s - 1 . We then use the theoretical model to predict VWF's behaviour in two complex flows where experimental data are challenging to obtain: pure elongational flow and ste...
Source: Biomechanics and Modeling in Mechanobiology - April 9, 2024 Category: Biomedical Science Authors: E F Yeo J M Oliver N Korin S L Waters Source Type: research
MSCTA imaging analysis of autologous arteriovenous fistula dysfunction in maintenance hemodialysis patients
CONCLUSION: MSCTA can be used to evaluate the dysfunction of autologous arteriovenous fistula in patients undergoing maintenance hemodialysis, and provide important reference information for the formulation of the next best clinical treatment plan.PMID:38586097 | PMC:PMC10994794 | DOI:10.62347/YEGN9292 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Yingjie Wang Yanlei Qin Xiaolu Huang Weihong Liu Source Type: research
