Combination therapy of vitamin C and thiamine for septic shock in a multicentre, double-blind, randomized, controlled study (ATESS): study protocol for a randomized controlled trial
This study is a randomized, double-blind, placebo-controlled, multicentre trial in adult patients with septic shock recruited from six emergency departments in South Korea. Patients will be randomly allocated into the treatment or control group (1:1 ratio), and we will recruit 116 septic shock patients (58 per group). For the treatment group, vitamin C (50 mg/kg) and thiamine (200 mg) will be mixed in 50 ml of 0.9% saline and administered intravenously every 12 h for a total of 48 h. For the placebo group, an identical volume of 0.9% saline will be administered in the same manner. The primary outcome is the delt...
Source: Trials - July 10, 2019 Category: Research Source Type: clinical trials
Efficacy and Safety of Nerve Growth Factor or Edaravone on Alcohol-induced Brain Injury
Condition: Alcohol-induced Brain Injury Interventions: Drug: Nerve Growth Factor; Drug: Edaravone; Drug: Combination of vitamin B1, B6, C, E and mecobalamine Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - May 30, 2019 Category: Research Source Type: clinical trials
