Extra-prostatic Transgene-associated Neoplastic Lesions in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice.
Abstract
Male transgenic adenocarcinoma of the mouse prostate (TRAMP) mice are frequently used in prostate cancer research because their prostates consistently develop a series of preneoplastic and neoplastic lesions. Disease progression in TRAMP mouse prostates culminates in metastatic, poorly differentiated carcinomas with neuroendocrine features. The androgen dependence of the rat probasin promoter largely limits transgene expression to the prostatic epithelium. However, extra-prostatic transgene-positive lesions have been described in TRAMP mice, including renal tubuloacinar carcinomas, neuroendocrine ...
Source: Toxicologic Pathology - April 17, 2014 Category: Pathology Authors: Berman-Booty LD, Thomas-Ahner JM, Bolon B, Oglesbee MJ, Clinton SK, Kulp SK, Chen CS, Perle KM Tags: Toxicol Pathol Source Type: research
Mp13-03 impact of synchronous bladder cancer on recurrence-free survival after surgical treatment for primary urethral cancer: results from the international collaboration on primary urethral carcinoma (icpuc)
(Source: The Journal of Urology)
Source: The Journal of Urology - April 1, 2014 Category: Urology & Nephrology Authors: Georgios Gakis, Jason A. Efstathiou, Todd Morgan, Sia Daneshmand, Kirk A. Keegan, Harras B. Zaid, Sam S. Chang, Bedeir Ali-El-Dein, Jan Hrbacek, Sigolene Galland, Tilman Todenhöfer, Lars Weissbach, Rebecca Clayman, Kola Olugbade, Michael Rink, Hans-Marti Tags: Urethra: Benign & Malignant Disease (MP13) Source Type: research
Mp13-08 gender influence on presentation, management, and overall survival in primary urethral cancer
(Source: The Journal of Urology)
Source: The Journal of Urology - April 1, 2014 Category: Urology & Nephrology Authors: Zachary Reardon, Harras Zaid, C.J. Stimson, Sanjay Patel, Samuel Kaffenberger, Matthew Resnick, Daniel Barocas, Sam Chang Tags: Urethra: Benign & Malignant Disease (MP13) Source Type: research
Management of Advanced Primary Urethral Carcinomas
Abstract
Primary urethral carcinoma (PUC) is a rare malignancy accounting for less than 1% of genitourinary cancers, with a predilection for men and African Americans. The sites and histology of urethral carcinoma vary by gender and anatomic location. Squamous cell carcinoma is most common among both genders but adenocarcinomas are noted in 15% to 35% of cases among women.
Obstructive or irritative symptoms and hematuria are common modes of presentation. Clinical evaluation includes cystourethroscopy with biopsy and examination under anesthesia. Magnetic resonance imaging provides a highly effective method to image the pri...
Source: BJU International - January 21, 2014 Category: Urology & Nephrology Authors: Farshid Dayyani, Karen Hoffman, Patricia Eifel, Charles Guo, Raghu Vikram, Lance C. Pagliaro, Curtis Pettaway Tags: Review Source Type: research
Re: Pathological Response to Neoadjuvant Chemotherapy for Muscle-Invasive Micropapillary Bladder Cancer
J. J. Meeks, J. M. Taylor, K. Matsushita, H. W. Herr, S. M. Donat, B. H. Bochner and G. Dalbagni Department of Surgery, Urology Service, Memorial Sloan-Kettering Cancer Center, New York, New York (Source: The Journal of Urology)
Source: The Journal of Urology - December 4, 2013 Category: Urology & Nephrology Authors: David P. Wood Tags: Urological Oncology: Bladder, Penis and Urethral Cancer, and Basic Principles of Oncology Source Type: research
Re: Novel Tumor Subgroups of Urothelial Carcinoma of the Bladder Defined by Integrated Genomic Analysis
C. D. Hurst, F. M. Platt, C. F. Taylor and M. A. Knowles Cancer Research UK Centre, Leeds Institute of Molecular Medicine, St. James’s University Hospital, Leeds, United Kingdom (Source: The Journal of Urology)
Source: The Journal of Urology - December 4, 2013 Category: Urology & Nephrology Authors: David P. Wood Tags: Urological Oncology: Bladder, Penis and Urethral Cancer, and Basic Principles of Oncology Source Type: research
Re: Intravesical Bacille Calmette-Guérin (BCG) in Immunologically Compromised Patients with Bladder Cancer
H. W. Herr and G. Dalbagni Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, New York (Source: The Journal of Urology)
Source: The Journal of Urology - December 2, 2013 Category: Urology & Nephrology Authors: David P. Wood Tags: Urological Oncology: Bladder, Penis and Urethral Cancer, and Basic Principles of Oncology Source Type: research
Re: Two Major Pathways of Penile Carcinogenesis: HPV-Induced Penile Cancers Overexpress p16ink4a, HPV-Negative Cancers Associated with Dermatoses Express p53, but Lack p16ink4a Overexpression
S. Mannweiler, S. Sygulla, E. Winter and S. Regauer Institute of Pathology, Medical University Graz, Graz, Austria (Source: The Journal of Urology)
Source: The Journal of Urology - December 2, 2013 Category: Urology & Nephrology Authors: David P. Wood Tags: Urological Oncology: Bladder, Penis and Urethral Cancer, and Basic Principles of Oncology Source Type: research
Docetaxel, cisplatin and 5‐fluorouracil chemotherapy with concurrent radiation for unresectable advanced urethral carcinoma
Abstract:
The present case report describes two cases of unresectable advanced primary urethral carcinoma. Case 1 was a 61‐year‐old man with squamous cell carcinoma of the urethra that directly invaded into the perineal skin. Case 2 was a 64‐year‐old woman with adenocarcinoma, and solitary lung and lymph node metastases. Both patients received docetaxel/cisplatin/5‐fluorouracil chemotherapy with concurrent radiation. The docetaxel/cisplatin/5‐fluorouracil chemotherapy regimen consisted of docetaxel (75 mg/m2) on day 2, cisplatin (100 mg/m2) on day 2 and 5‐fluorouracil (1000 mg/m2) on days 1 to 5 and ...
Source: International Journal of Urology - November 19, 2013 Category: Urology & Nephrology Authors: Jun Itoh, Koji Mitsuzuka, Shingo Kimura, Takaki Tanaka, Taku Yamamuro, Shinichi Yamashita, Shigeyuki Yamada, Hideo Saito, Yasuhiro Kaiho, Yoichi Arai Tags: Case Report Source Type: research
Editorial Comment to Docetaxel, cisplatin and 5‐fluorouracil chemotherapy with concurrent radiation for unresectable advanced urethral carcinoma
(Source: International Journal of Urology)
Source: International Journal of Urology - November 19, 2013 Category: Urology & Nephrology Authors: Georgios Gakis Tags: Editorial Comment Source Type: research
Magnetic resonance imaging of female urethral and periurethral disorders.
This article reviews the normal anatomy of the female urethra, magnetic resonance (MR) imaging techniques, and the role of MR imaging in the evaluation of diverse urethral and periurethral diseases. Salient MR imaging findings of common and uncommon cystic urethral lesions (urethral diverticulum, Skene cyst, and vaginal cysts), and masses (urethral carcinoma, leiomyoma, melanoma, fibroepithelial polyp, caruncle, and mucosal prolapse) are presented. The evolving role of dynamic MR in the evaluation of stress urinary incontinence is reviewed.
PMID: 24210437 [PubMed - in process] (Source: Radiologic Clinics of North America)
Source: Radiologic Clinics of North America - November 1, 2013 Category: Radiology Authors: Surabhi VR, Menias CO, George V, Siegel CL, Prasad SR Tags: Radiol Clin North Am Source Type: research
Magnetic Resonance Imaging of Female Urethral and Periurethral Disorders
This article reviews the normal anatomy of the female urethra, magnetic resonance (MR) imaging techniques, and the role of MR imaging in the evaluation of diverse urethral and periurethral diseases. Salient MR imaging findings of common and uncommon cystic urethral lesions (urethral diverticulum, Skene cyst, and vaginal cysts), and masses (urethral carcinoma, leiomyoma, melanoma, fibroepithelial polyp, caruncle, and mucosal prolapse) are presented. The evolving role of dynamic MR in the evaluation of stress urinary incontinence is reviewed. (Source: Radiologic Clinics of North America)
Source: Radiologic Clinics of North America - November 1, 2013 Category: Radiology Authors: Venkateswar Rao Surabhi, Christine O. Menias, Verghese George, Cary Lynn Siegel, Srinivasa R. Prasad Source Type: research
Re: Role of Marker Lesion When Applying Intravesical Instillations of IL-2 for Non-Muscle-Invasive Bladder Cancer Comparison of the Therapeutic Effects in Two Pilot Studies
W. Den Otter, R. J. Van Moorselaar, J. J. Jacobs, R. T. Haar, J. W. Koten, Z. Dobrowolski, W. Lipczynski, V. Pašukonienė, D. Characiejus, F. Jankevičius, R. Eidukevičius and T. M. De Reijke (Source: The Journal of Urology)
Source: The Journal of Urology - October 31, 2013 Category: Urology & Nephrology Authors: David P. Wood Tags: Urological Oncology: Bladder, Penis and Urethral Cancer, and Basic Principles of Oncology Source Type: research
Re: Comparative Outcomes of Primary, Recurrent, and Progressive High-Risk Non-Muscle-Invasive Bladder Cancer
F. Thomas, A. P. Noon, N. Rubin, J. R. Goepel and J. W. Catto Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom (Source: The Journal of Urology)
Source: The Journal of Urology - October 31, 2013 Category: Urology & Nephrology Authors: David P. Wood Tags: Urological Oncology: Bladder, Penis and Urethral Cancer, and Basic Principles of Oncology Source Type: research
Re: Final Results of an EORTC-GU Cancers Group Randomized Study of Maintenance Bacillus Calmette-Guérin in Intermediate- and High-Risk Ta, T1 Papillary Carcinoma of the Urinary Bladder: One-Third Dose versus Full Dose and 1 Year versus 3 Years of Maintenance
J. Oddens, M. Brausi, R. Sylvester, A. Bono, C. van de Beek, G. van Andel, P. Gontero, W. Hoeltl, L. Turkeri, S. Marreaud, S. Collette and W. Oosterlinck Department of Urology, Jeroen Bosch Ziekenhuis, 's-Hertogenbosch, The Netherlands (Source: The Journal of Urology)
Source: The Journal of Urology - October 30, 2013 Category: Urology & Nephrology Authors: David P. Wood Tags: Urological Oncology: Bladder, Penis and Urethral Cancer, and Basic Principles of Oncology Source Type: research
