African American Study of Kidney Disease and Hypertension
Conditions: Hypertensive Nephrosclerosis; Chronic Renal Insufficiency Interventions: Other: MAP goal less than or equal to 92 mm Hg; Other: MAP goal 102-107 mm Hg; Drug: Ramipril; Drug: Amlodipine; Drug: Metoprolol Sponsors: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); The Cleveland Clinic Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 27, 2020 Category: Research Source Type: clinical trials
Update on the EFFECTS study of fluoxetine for stroke recovery: a randomised controlled trial in Sweden
ConclusionEFFECTS will provide data on the safety and efficacy of 6 months of treatment with fluoxetine after stroke in a Swedish health system setting. The data from EFFECTS will also contribute to an individual patient data meta-analysis.Trial registrationEudraCT 2011-006130-16. Registered on 8 August 2014.ISRCTN, ISRCTN13020412. Registered on 19 December 2014.ClinicalTrials.gov:NCT02683213. Retrospectively registered on 2 February 2016. (Source: Trials)
Source: Trials - February 27, 2020 Category: Research Source Type: clinical trials
Beta-blockeRs tO patieNts with CHronIc Obstructive puLmonary diseasE (BRONCHIOLE) – Study protocol from a randomized controlled trial
DiscussionBRONCHIOLE is a pragmatic randomized trial addressing the potential of beta-blockers in patients with COPD. The trial is expected to provide relevant clinical data on the efficacy of this treatment on patient-related outcomes in patients with COPD.Trial registrationClinicalTrials.gov, ID:NCT03566667. Registered on 25 June 2018. (Source: Trials)
Source: Trials - January 29, 2020 Category: Research Source Type: clinical trials
Results and lessons learnt from a randomized controlled trial: prophylactic treatment of vestibular migraine with metoprolol (PROVEMIG)
ConclusionsAfter randomizing 130 patients PROVEMIG had to be discontinued because of poor participant accrual not related to the tolerability of the study medication or safety concerns; no treatment benefit of metoprolol over placebo could be established. Additional preparatory work is much needed in the development, psychometric evaluation and interpretation of clinically meaningful end points in trials on episodic syndromes like VM taking into consideration the complexity of this disease entity comprising two domains (vertigo- and headache-related disability).Trial registrationEudraCT,2009-013701-34. Prospectively regist...
Source: Trials - December 29, 2019 Category: Research Source Type: clinical trials
Effect of Metoprolol in Post Alcohol Septal Ablation Patients With Hypertrophic Cardiomyopathy
Condition: Hypertrophic Cardiomyopathy Intervention: Drug: Metoprolol Sponsor: University Hospital, Motol Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 21, 2019 Category: Research Source Type: clinical trials
