Autogenic splenic implantation versus splenectomy in patients undergoing distal pancreatectomy for benign or low-grade malignant lesions of the distal pancreas: study protocol for a multicentre, open-label, randomized controlled trial (RESTORE)
This study will investigate the splenic immune function of patients who undergo ASI during minimally invasive distal pancreatectomy with splenectomy. The splenic immune function will be measured using the surrogate outcome of specific antibody titre after vaccination with aSalmonella typhi vaccine. The results will reveal details about splenic function after ASI and guide further treatment options for patients when a splenectomy cannot be avoided. It might eventually lead to a new standard of care making sometimes more demanding and time-consuming spleen-preserving procedures redundant.Trial registrationInternational Stand...
Source: Trials - January 9, 2024 Category: Research Source Type: clinical trials

Meningococcal B Vaccine in Patients With Asplenia
Condition:   Splenectomy; Status Intervention:   Biological: Bexsero Sponsor:   Medical University of Vienna Not yet recruiting (Source:
Source: - September 6, 2023 Category: Research Source Type: clinical trials

Post Splenectomy Infections After Surgery for Peritoneal Malignancies (OPSI)
Conditions:   Post-Splenectomy Infection;   Peritoneal Cancer Intervention:   Other: Questionnaire, interview or observation study Sponsor:   Hampshire Hospitals NHS Foundation Trust Recruiting (Source:
Source: - February 8, 2023 Category: Research Source Type: clinical trials