Tiotropium for refractory cough in asthma via cough reflex sensitivity: a randomized, parallel, open-label, trial
CONCLUSION: Tiotropium may alleviate chronic cough in asthma refractory to ICS/LABA by modulating C-CRS. Heightened C-CRS may predict responsiveness to tiotropium for refractory cough in asthma.PMID:37030486 | DOI:10.1016/j.anai.2023.03.032 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 8, 2023 Category: Allergy & Immunology Authors: Kensuke Fukumitsu Yoshihiro Kanemitsu Ryota Kurokawa Norihisa Takeda Tomoko Tajiri Hirono Nishiyama Keima Ito Yoshitsugu Inoue Sayaka Yamamoto Yuta Mori Satoshi Fukuda Takehiro Uemura Hirotsugu Ohkubo Ken Maeno Yutaka Ito Tetsuya Oguri Masaya Takemura Aki Source Type: research
Tiotropium for refractory cough in asthma via cough reflex sensitivity: a randomized, parallel, open-label, trial
CONCLUSION: Tiotropium may alleviate chronic cough in asthma refractory to ICS/LABA by modulating C-CRS. Heightened C-CRS may predict responsiveness to tiotropium for refractory cough in asthma.PMID:37030486 | DOI:10.1016/j.anai.2023.03.032 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 8, 2023 Category: Allergy & Immunology Authors: Kensuke Fukumitsu Yoshihiro Kanemitsu Ryota Kurokawa Norihisa Takeda Tomoko Tajiri Hirono Nishiyama Keima Ito Yoshitsugu Inoue Sayaka Yamamoto Yuta Mori Satoshi Fukuda Takehiro Uemura Hirotsugu Ohkubo Ken Maeno Yutaka Ito Tetsuya Oguri Masaya Takemura Aki Source Type: research
Tiotropium for refractory cough in asthma via cough reflex sensitivity: a randomized, parallel, open-label, trial
We previously reported in an uncontrolled study that tiotropium alleviated chronic cough in asthma refractory to inhaled corticosteroids and long-acting β2 agonists (ICS/LABA) by modulating capsaicin cough reflex sensitivity (C-CRS). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 6, 2023 Category: Allergy & Immunology Authors: Kensuke Fukumitsu, Yoshihiro Kanemitsu, Ryota Kurokawa, Norihisa Takeda, Tomoko Tajiri, Hirono Nishiyama, Keima Ito, Yoshitsugu Inoue, Sayaka Yamamoto, Yuta Mori, Satoshi Fukuda, Takehiro Uemura, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Mas Tags: Original Article Source Type: research
Tiotropium Bromide Improves Neutrophilic Asthma by Recovering Histone Deacetylase 2 Activity
CONCLUSION: These results support the hypothesis that TIO modulates inflammation by recovering HDAC2 activity from the acetylcholine-stimulated inflammation cascade in neutrophilic asthma. The detailed inflammation cascade of recovering HDAC2 activity by TIO might be associated with PLCγ-1-IP3-IP3R mediated intracellular calcium ion pathway.PMID:36974400 | DOI:10.3346/jkms.2023.38.e91 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - March 28, 2023 Category: Biomedical Science Authors: Tai Joon An Ji Hye Kim Jung Hur Chan Kwon Park Jeong Uk Lim Seohyun Kim Chin Kook Rhee Hyoung Kyu Yoon Source Type: research
Tiotropium Bromide Improves Neutrophilic Asthma by Recovering Histone Deacetylase 2 Activity
CONCLUSION: These results support the hypothesis that TIO modulates inflammation by recovering HDAC2 activity from the acetylcholine-stimulated inflammation cascade in neutrophilic asthma. The detailed inflammation cascade of recovering HDAC2 activity by TIO might be associated with PLCγ-1-IP3-IP3R mediated intracellular calcium ion pathway.PMID:36974400 | DOI:10.3346/jkms.2023.38.e91 (Source: J Korean Med Sci)
Source: J Korean Med Sci - March 28, 2023 Category: General Medicine Authors: Tai Joon An Ji Hye Kim Jung Hur Chan Kwon Park Jeong Uk Lim Seohyun Kim Chin Kook Rhee Hyoung Kyu Yoon Source Type: research
Tiotropium Bromide Improves Neutrophilic Asthma by Recovering Histone Deacetylase 2 Activity
CONCLUSION: These results support the hypothesis that TIO modulates inflammation by recovering HDAC2 activity from the acetylcholine-stimulated inflammation cascade in neutrophilic asthma. The detailed inflammation cascade of recovering HDAC2 activity by TIO might be associated with PLCγ-1-IP3-IP3R mediated intracellular calcium ion pathway.PMID:36974400 | PMC:PMC10042725 | DOI:10.3346/jkms.2023.38.e91 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - March 28, 2023 Category: Biomedical Science Authors: Tai Joon An Ji Hye Kim Jung Hur Chan Kwon Park Jeong Uk Lim Seohyun Kim Chin Kook Rhee Hyoung Kyu Yoon Source Type: research
Tiotropium Bromide Improves Neutrophilic Asthma by Recovering Histone Deacetylase 2 Activity
CONCLUSION: These results support the hypothesis that TIO modulates inflammation by recovering HDAC2 activity from the acetylcholine-stimulated inflammation cascade in neutrophilic asthma. The detailed inflammation cascade of recovering HDAC2 activity by TIO might be associated with PLCγ-1-IP3-IP3R mediated intracellular calcium ion pathway.PMID:36974400 | PMC:PMC10042725 | DOI:10.3346/jkms.2023.38.e91 (Source: J Korean Med Sci)
Source: J Korean Med Sci - March 28, 2023 Category: General Medicine Authors: Tai Joon An Ji Hye Kim Jung Hur Chan Kwon Park Jeong Uk Lim Seohyun Kim Chin Kook Rhee Hyoung Kyu Yoon Source Type: research
Tiotropium Bromide Improves Neutrophilic Asthma by Recovering Histone Deacetylase 2 Activity
CONCLUSION: These results support the hypothesis that TIO modulates inflammation by recovering HDAC2 activity from the acetylcholine-stimulated inflammation cascade in neutrophilic asthma. The detailed inflammation cascade of recovering HDAC2 activity by TIO might be associated with PLCγ-1-IP3-IP3R mediated intracellular calcium ion pathway.PMID:36974400 | PMC:PMC10042725 | DOI:10.3346/jkms.2023.38.e91 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - March 28, 2023 Category: Biomedical Science Authors: Tai Joon An Ji Hye Kim Jung Hur Chan Kwon Park Jeong Uk Lim Seohyun Kim Chin Kook Rhee Hyoung Kyu Yoon Source Type: research
Tiotropium Bromide Improves Neutrophilic Asthma by Recovering Histone Deacetylase 2 Activity
CONCLUSION: These results support the hypothesis that TIO modulates inflammation by recovering HDAC2 activity from the acetylcholine-stimulated inflammation cascade in neutrophilic asthma. The detailed inflammation cascade of recovering HDAC2 activity by TIO might be associated with PLCγ-1-IP3-IP3R mediated intracellular calcium ion pathway.PMID:36974400 | PMC:PMC10042725 | DOI:10.3346/jkms.2023.38.e91 (Source: J Korean Med Sci)
Source: J Korean Med Sci - March 28, 2023 Category: General Medicine Authors: Tai Joon An Ji Hye Kim Jung Hur Chan Kwon Park Jeong Uk Lim Seohyun Kim Chin Kook Rhee Hyoung Kyu Yoon Source Type: research
Tiotropium Bromide Improves Neutrophilic Asthma by Recovering Histone Deacetylase 2 Activity
CONCLUSION: These results support the hypothesis that TIO modulates inflammation by recovering HDAC2 activity from the acetylcholine-stimulated inflammation cascade in neutrophilic asthma. The detailed inflammation cascade of recovering HDAC2 activity by TIO might be associated with PLCγ-1-IP3-IP3R mediated intracellular calcium ion pathway.PMID:36974400 | PMC:PMC10042725 | DOI:10.3346/jkms.2023.38.e91 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - March 28, 2023 Category: Biomedical Science Authors: Tai Joon An Ji Hye Kim Jung Hur Chan Kwon Park Jeong Uk Lim Seohyun Kim Chin Kook Rhee Hyoung Kyu Yoon Source Type: research
Tiotropium Bromide Improves Neutrophilic Asthma by Recovering Histone Deacetylase 2 Activity
CONCLUSION: These results support the hypothesis that TIO modulates inflammation by recovering HDAC2 activity from the acetylcholine-stimulated inflammation cascade in neutrophilic asthma. The detailed inflammation cascade of recovering HDAC2 activity by TIO might be associated with PLCγ-1-IP3-IP3R mediated intracellular calcium ion pathway.PMID:36974400 | PMC:PMC10042725 | DOI:10.3346/jkms.2023.38.e91 (Source: J Korean Med Sci)
Source: J Korean Med Sci - March 28, 2023 Category: General Medicine Authors: Tai Joon An Ji Hye Kim Jung Hur Chan Kwon Park Jeong Uk Lim Seohyun Kim Chin Kook Rhee Hyoung Kyu Yoon Source Type: research
Tiotropium Bromide Improves Neutrophilic Asthma by Recovering Histone Deacetylase 2 Activity
CONCLUSION: These results support the hypothesis that TIO modulates inflammation by recovering HDAC2 activity from the acetylcholine-stimulated inflammation cascade in neutrophilic asthma. The detailed inflammation cascade of recovering HDAC2 activity by TIO might be associated with PLCγ-1-IP3-IP3R mediated intracellular calcium ion pathway.PMID:36974400 | PMC:PMC10042725 | DOI:10.3346/jkms.2023.38.e91 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - March 28, 2023 Category: Biomedical Science Authors: Tai Joon An Ji Hye Kim Jung Hur Chan Kwon Park Jeong Uk Lim Seohyun Kim Chin Kook Rhee Hyoung Kyu Yoon Source Type: research
Tiotropium Bromide Improves Neutrophilic Asthma by Recovering Histone Deacetylase 2 Activity
CONCLUSION: These results support the hypothesis that TIO modulates inflammation by recovering HDAC2 activity from the acetylcholine-stimulated inflammation cascade in neutrophilic asthma. The detailed inflammation cascade of recovering HDAC2 activity by TIO might be associated with PLCγ-1-IP3-IP3R mediated intracellular calcium ion pathway.PMID:36974400 | PMC:PMC10042725 | DOI:10.3346/jkms.2023.38.e91 (Source: J Korean Med Sci)
Source: J Korean Med Sci - March 28, 2023 Category: General Medicine Authors: Tai Joon An Ji Hye Kim Jung Hur Chan Kwon Park Jeong Uk Lim Seohyun Kim Chin Kook Rhee Hyoung Kyu Yoon Source Type: research
Tiotropium Bromide Improves Neutrophilic Asthma by Recovering Histone Deacetylase 2 Activity
CONCLUSION: These results support the hypothesis that TIO modulates inflammation by recovering HDAC2 activity from the acetylcholine-stimulated inflammation cascade in neutrophilic asthma. The detailed inflammation cascade of recovering HDAC2 activity by TIO might be associated with PLCγ-1-IP3-IP3R mediated intracellular calcium ion pathway.PMID:36974400 | PMC:PMC10042725 | DOI:10.3346/jkms.2023.38.e91 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - March 28, 2023 Category: Biomedical Science Authors: Tai Joon An Ji Hye Kim Jung Hur Chan Kwon Park Jeong Uk Lim Seohyun Kim Chin Kook Rhee Hyoung Kyu Yoon Source Type: research
