Tiotropium Bromide Improves Neutrophilic Asthma by Recovering Histone Deacetylase 2 Activity
CONCLUSION: These results support the hypothesis that TIO modulates inflammation by recovering HDAC2 activity from the acetylcholine-stimulated inflammation cascade in neutrophilic asthma. The detailed inflammation cascade of recovering HDAC2 activity by TIO might be associated with PLCĪ³-1-IP3-IP3R mediated intracellular calcium ion pathway.PMID:36974400 | PMC:PMC10042725 | DOI:10.3346/jkms.2023.38.e91 (Source: J Korean Med Sci)
Source: J Korean Med Sci - March 28, 2023 Category: General Medicine Authors: Tai Joon An Ji Hye Kim Jung Hur Chan Kwon Park Jeong Uk Lim Seohyun Kim Chin Kook Rhee Hyoung Kyu Yoon Source Type: research
Tiotropium in Patients with Bronchiectasis: A Prospective Cohort Study
ConclusionIn conclusion, prospective cohort study showed that tiotropium effectively ameliorated the annual decline in the FEV1, with a lower-risk rate of moderate exacerbations and prolonging the time to the first-time severe exacerbation in patients with bronchiectasis and airflow limitation. (Source: Lung)
Source: Lung - February 7, 2023 Category: Respiratory Medicine Source Type: research
Therapeutic potential of thiophene compounds: a mini-review
Mini Rev Med Chem. 2023 Feb 6. doi: 10.2174/1389557523666230206104257. Online ahead of print.ABSTRACTA rising number of researchers are interested in thiophene-based analogs as they have wide possibilities of biological potential in the largely developing chemical world of the heterocyclic moiety. It also occupies a central position in synthetic organic chemistry and is of the highest theoretical and practical importance. It became an important moiety for researchers to discover combinatorial libraries and implement the efforts in search of the lead entity. Moreover, it helps medicinal chemists to improve sophisticated mol...
Source: Mini Reviews in Medicinal Chemistry - February 6, 2023 Category: Chemistry Authors: Shivani Chawla Shweta Sharma Sarfraj Kashid Prabhakar Kumar Verma Ashu Sapra Source Type: research
Therapeutic potential of thiophene compounds: a mini-review
Mini Rev Med Chem. 2023 Feb 6. doi: 10.2174/1389557523666230206104257. Online ahead of print.ABSTRACTA rising number of researchers are interested in thiophene-based analogs as they have wide possibilities of biological potential in the largely developing chemical world of the heterocyclic moiety. It also occupies a central position in synthetic organic chemistry and is of the highest theoretical and practical importance. It became an important moiety for researchers to discover combinatorial libraries and implement the efforts in search of the lead entity. Moreover, it helps medicinal chemists to improve sophisticated mol...
Source: Mini Reviews in Medicinal Chemistry - February 6, 2023 Category: Chemistry Authors: Shivani Chawla Shweta Sharma Sarfraj Kashid Prabhakar Kumar Verma Ashu Sapra Source Type: research
Therapeutic potential of thiophene compounds: a mini-review
Mini Rev Med Chem. 2023 Feb 6. doi: 10.2174/1389557523666230206104257. Online ahead of print.ABSTRACTA rising number of researchers are interested in thiophene-based analogs as they have wide possibilities of biological potential in the largely developing chemical world of the heterocyclic moiety. It also occupies a central position in synthetic organic chemistry and is of the highest theoretical and practical importance. It became an important moiety for researchers to discover combinatorial libraries and implement the efforts in search of the lead entity. Moreover, it helps medicinal chemists to improve sophisticated mol...
Source: Mini Reviews in Medicinal Chemistry - February 6, 2023 Category: Chemistry Authors: Shivani Chawla Shweta Sharma Sarfraj Kashid Prabhakar Kumar Verma Ashu Sapra Source Type: research
Efficacy and safety of tiotropium bromide inhalation in symptomatic patients with chronic obstructive pulmonary disease: A multicenter, prospective, and observational study
CONCLUSION: TBI for 3 months could effectively and safely attenuate symptoms and airflow obstruction in symptomatic Chinese patients with COPD.PMID:36714923 | DOI:10.1080/17476348.2023.2171990 (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - January 30, 2023 Category: Respiratory Medicine Authors: Yue Liao Hao Wang Ke Wang Kai Zi Yongchun Shen Lei Chen Tao Wang Jun Chen Fuqiang Wen Source Type: research
Efficacy and safety of tiotropium bromide inhalation in symptomatic patients with chronic obstructive pulmonary disease: A multicenter, prospective, and observational study
CONCLUSION: TBI for 3 months could effectively and safely attenuate symptoms and airflow obstruction in symptomatic Chinese patients with COPD.PMID:36714923 | DOI:10.1080/17476348.2023.2171990 (Source: Respiratory Care)
Source: Respiratory Care - January 30, 2023 Category: Respiratory Medicine Authors: Yue Liao Hao Wang Ke Wang Kai Zi Yongchun Shen Lei Chen Tao Wang Jun Chen Fuqiang Wen Source Type: research
Efficacy and safety of tiotropium bromide inhalation in symptomatic patients with chronic obstructive pulmonary disease: A multicenter, prospective, and observational study
CONCLUSION: TBI for 3 months could effectively and safely attenuate symptoms and airflow obstruction in symptomatic Chinese patients with COPD.PMID:36714923 | DOI:10.1080/17476348.2023.2171990 (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - January 30, 2023 Category: Respiratory Medicine Authors: Yue Liao Hao Wang Ke Wang Kai Zi Yongchun Shen Lei Chen Tao Wang Jun Chen Fuqiang Wen Source Type: research
Efficacy and safety of tiotropium bromide inhalation in symptomatic patients with chronic obstructive pulmonary disease: A multicenter, prospective, and observational study
CONCLUSION: TBI for 3 months could effectively and safely attenuate symptoms and airflow obstruction in symptomatic Chinese patients with COPD.PMID:36714923 | DOI:10.1080/17476348.2023.2171990 (Source: Respiratory Care)
Source: Respiratory Care - January 30, 2023 Category: Respiratory Medicine Authors: Yue Liao Hao Wang Ke Wang Kai Zi Yongchun Shen Lei Chen Tao Wang Jun Chen Fuqiang Wen Source Type: research
Efficacy and safety of tiotropium bromide inhalation in symptomatic patients with chronic obstructive pulmonary disease: A multicenter, prospective, and observational study
CONCLUSION: TBI for 3 months could effectively and safely attenuate symptoms and airflow obstruction in symptomatic Chinese patients with COPD.PMID:36714923 | DOI:10.1080/17476348.2023.2171990 (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - January 30, 2023 Category: Respiratory Medicine Authors: Yue Liao Hao Wang Ke Wang Kai Zi Yongchun Shen Lei Chen Tao Wang Jun Chen Fuqiang Wen Source Type: research
Mometasone/Indacaterol/Glycopyrronium (MF/IND/GLY) and MF/IND at Different MF Strengths versus Fluticasone Propionate/Salmeterol Xinafoate (FLU/SAL) and FLU/SAL+ Tiotropium in Patients with Asthma
(Source: Journal of Asthma and Allergy)
Source: Journal of Asthma and Allergy - January 19, 2023 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Utilization of exacerbation-related drugs by COPD patients with Arg16Gly polymorphism of ADRB2 gene
Conclusions: ADRB2 gene might alter activity of the receptor leading to its malfunctions and malcommunication at the cellular level leading to the higher need in antibiotics and GCS in some groups. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Dmytriiev, K., Mostovoy, Y., Slepchenko, N., Smereka, Y., Dmytriiev, D., Dmytriieva, K. Tags: 05.01 - Airway pharmacology and treatment Source Type: research
COPD clinical course in patient with Gln27Glu polymorphism of ADRB2 gene
Conclusions: Gln27Glu polymorphism can contribute to the clinical course of COPD providing a difference in the clinical groups prevalence. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Dmytriiev, K., Mostovoy, Y., Slepchenko, N., Smereka, Y., Dmytriiev, D., Dmytriiev, K. Tags: 05.01 - Airway pharmacology and treatment Source Type: research
How COPD patients with Gln27Glu polymorphism utilize exacerbation-related drugs?
Conclusions: Gln27Glu polymorphism of ADRB2 gene can be involved in the cross-talk between different receptor and promote greater GCS need in COPD patients. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Dmytriiev, K., Mostovoy, Y., Slepchenko, N., Smereka, Y., Dmytriiev, D. Tags: 01.01 - Clinical problems - no related to asthma or COPD Source Type: research
