N-of-1 medicine
Singapore Med J. 2024 Mar 1;65(3):167-175. doi: 10.4103/singaporemedj.SMJ-2023-243. Epub 2024 Mar 26.ABSTRACTThe fields of precision and personalised medicine have led to promising advances in tailoring treatment to individual patients. Examples include genome/molecular alteration-guided drug selection, single-patient gene therapy design and synergy-based drug combination development, and these approaches can yield substantially diverse recommendations. Therefore, it is important to define each domain and delineate their commonalities and differences in an effort to develop novel clinical trial designs, streamline workflow...
Source: Singapore Medical Journal - March 25, 2024 Category: General Medicine Authors: Peter Wang Qiao Ying Leong Ni Yin Lau Wei Ying Ng Siong Peng Kwek Lester Tan Shang-Wei Song Kui You Li Ming Chong Isaiah Zhuang Yoong Hun Ong Nigel Foo Xavier Tadeo Kirthika Senthil Kumar Smrithi Vijayakumar Yoann Sapanel Marlena Natalia Raczkowska Alexan Source Type: research
Medical education and physician training in the era of artificial intelligence
Singapore Med J. 2024 Mar 1;65(3):159-166. doi: 10.4103/singaporemedj.SMJ-2023-203. Epub 2024 Mar 26.ABSTRACTWith the rise of generative artificial intelligence (AI) and AI-powered chatbots, the landscape of medicine and healthcare is on the brink of significant transformation. This perspective delves into the prospective influence of AI on medical education, residency training and the continuing education of attending physicians or consultants. We begin by highlighting the constraints of the current education model, challenges in limited faculty, uniformity amidst burgeoning medical knowledge and the limitations in 'tradi...
Source: Singapore Medical Journal - March 25, 2024 Category: General Medicine Authors: Yueyuan Xu Zehua Jiang Daniel Shu Wei Ting Alfred Wei Chieh Kow Fernando Bello Josip Car Yih-Chung Tham Tien Yin Wong Source Type: research
Ethics of artificial intelligence in medicine
This article reviews the main ethical issues that arise from the use of artificial intelligence (AI) technologies in medicine. Issues around trust, responsibility, risks of discrimination, privacy, autonomy, and potential benefits and harms are assessed. For better or worse, AI is a promising technology that can revolutionise healthcare delivery. It is up to us to make AI a tool for the good by ensuring that ethical oversight accompanies the design, development and implementation of AI technology in clinical practice.PMID:38527299 | DOI:10.4103/singaporemedj.SMJ-2023-279 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - March 25, 2024 Category: General Medicine Authors: Julian Savulescu Alberto Giubilini Robert Vandersluis Abhishek Mishra Source Type: research
Artificial intelligence-based video monitoring of movement disorders in the elderly: a review on current and future landscapes
Singapore Med J. 2024 Mar 1;65(3):141-149. doi: 10.4103/singaporemedj.SMJ-2023-189. Epub 2024 Mar 26.ABSTRACTDue to global ageing, the burden of chronic movement and neurological disorders (Parkinson's disease and essential tremor) is rapidly increasing. Current diagnosis and monitoring of these disorders rely largely on face-to-face assessments utilising clinical rating scales, which are semi-subjective and time-consuming. To address these challenges, the utilisation of artificial intelligence (AI) has emerged. This review explores the advantages and challenges associated with using AI-driven video monitoring to care for ...
Source: Singapore Medical Journal - March 25, 2024 Category: General Medicine Authors: Kye Won Park Maryam S Mirian Martin J McKeown Source Type: research
Development and validation of a deep learning system for detection of small bowel pathologies in capsule endoscopy: a pilot study in a Singapore institution
CONCLUSION: Our pilot models showed the potential to improve time to diagnosis in CE workflows. To our knowledge, our approach is unique to the Singapore context. The value of our work can be further evaluated in a pragmatic manner that is sensitive to existing clinician workflow and resource constraints.PMID:38527297 | DOI:10.4103/singaporemedj.SMJ-2023-187 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - March 25, 2024 Category: General Medicine Authors: Bochao Jiang Michael Dorosan Justin Wen Hao Leong Marcus Eng Hock Ong Sean Shao Wei Lam Tiing Leong Ang Source Type: research
Introduction to artificial intelligence in medicine
Singapore Med J. 2024 Mar 1;65(3):132. doi: 10.4103/singaporemedj.SMJ-2024-060. Epub 2024 Mar 26.NO ABSTRACTPMID:38527296 | DOI:10.4103/singaporemedj.SMJ-2024-060 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - March 25, 2024 Category: General Medicine Authors: Joseph J Y Sung Source Type: research
Artificial intelligence in medicine
Singapore Med J. 2024 Mar 1;65(3):131. doi: 10.4103/singaporemedj.SMJ-2024-059. Epub 2024 Mar 26.NO ABSTRACTPMID:38527295 | DOI:10.4103/singaporemedj.SMJ-2024-059 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - March 25, 2024 Category: General Medicine Authors: Mahesh Choolani Source Type: research
Alleviating misclassified germline variants in underrepresented populations: a strategy using popmax
CONCLUSION: Underrepresented population-groups can suffer from higher rates of false positive P/LP results. Popmax can partially alleviate these misclassifications, but its efficacy still depends on the degree with which the population-groups is represented in the control cohort.PMID:38522067 | DOI:10.1016/j.gim.2024.101124 (Source: Cancer Control)
Source: Cancer Control - March 24, 2024 Category: Cancer & Oncology Authors: Ning Yuan Lee Melissa Hum Matthew Wong Pei-Yi Ong Soo-Chin Lee Ann S G Lee Source Type: research
Source emission contributions to particulate matter and ozone, and their health impacts in Southeast Asia
Environ Int. 2024 Mar 18;186:108578. doi: 10.1016/j.envint.2024.108578. Online ahead of print.ABSTRACTSoutheast Asia has been experiencing severe air pollution due to its substantial local emissions and transboundary air pollution (TAP), causing significant health impacts. While literature focused on air pollution episodes in Southeast Asia, we have yet to fully understand the contributions of local emission sectors and TAP to air quality in the region annually. Herein we employed air quality modeling with the species tagging method to first assess the contributions of source sectors and locations to fine particulate matte...
Source: Environment International - March 24, 2024 Category: Environmental Health Authors: Yefu Gu Tingting Fang Steve Hung Lam Yim Source Type: research
Source emission contributions to particulate matter and ozone, and their health impacts in Southeast Asia
Environ Int. 2024 Mar 18;186:108578. doi: 10.1016/j.envint.2024.108578. Online ahead of print.ABSTRACTSoutheast Asia has been experiencing severe air pollution due to its substantial local emissions and transboundary air pollution (TAP), causing significant health impacts. While literature focused on air pollution episodes in Southeast Asia, we have yet to fully understand the contributions of local emission sectors and TAP to air quality in the region annually. Herein we employed air quality modeling with the species tagging method to first assess the contributions of source sectors and locations to fine particulate matte...
Source: Environment International - March 24, 2024 Category: Environmental Health Authors: Yefu Gu Tingting Fang Steve Hung Lam Yim Source Type: research
The Cost-Effectiveness of an Advanced Hybrid Closed-Loop System Compared to Standard Management of Type 1 Diabetes in a Singapore Setting
Diabetes Technology&Therapeutics, Ahead of Print. (Source: Diabetes Technology)
Source: Diabetes Technology - March 22, 2024 Category: Endocrinology Authors: Daphne Gardner Mrinmayee Lakkad Zhiyu Qiu Yuta Inoue Suresh Rama Chandran Kael Wherry Source Type: research
Association between deep learning measured retinal vessel calibre and incident myocardial infarction in a retrospective cohort from the UK Biobank
Conclusion
Our results support DL-based retinal vessel measurements as markers of incident MI in a predominantly Caucasian population. (Source: BMJ Open)
Source: BMJ Open - March 21, 2024 Category: General Medicine Authors: Wong, Y. L., Yu, M., Chong, C., Yang, D., Xu, D., Lee, M. L., Hsu, W., Wong, T. Y., Cheng, C., Cheung, C. Y. Tags: Open access, Ophthalmology Source Type: research
The influence of socio-economic status on child temperament and psychological symptom profiles
Br J Psychol. 2024 Mar 20. doi: 10.1111/bjop.12701. Online ahead of print.ABSTRACTThe influence of socio-economic status (SES) on child temperament and psychological symptoms was examined using a nationally representative sample in Singapore. Data were available for 2169 children from 1987 families. Caregivers' reports were obtained on children aged 4-6. SES was operationalized as an aggregation of household income per capita, parental education level and housing type. Compared to their counterparts from higher SES families, children from low-SES families tended to exhibit (a) higher negative affectivity but lower effortfu...
Source: British Journal of Psychology - March 20, 2024 Category: Psychiatry & Psychology Authors: Ryan Y Hong Xiao Pan Ding Kelly M Y Chan Wei-Jun Jean Yeung Source Type: research
A comparison of GOLD 2019 and 2023 recommendations to contemporaneous real-world inhaler treatment patterns for chronic obstructive pulmonary disease management in Singapore
CONCLUSIONS: Compared with real-world clinical practice, a significantly higher proportion of patients may be eligible for treatment escalation under the GOLD 2019 and 2023 eosinophil-directed algorithms.PMID:38505044 | PMC:PMC10944796 | DOI:10.21037/jtd-22-1769 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Rayan Alsuwaigh Anthony Yii Chee Hong Loh Xiaomeng Xu Priti Bahety Aldo A Navarro Rojas Dominique Milea Augustine Tee Source Type: research
The influence of socio-economic status on child temperament and psychological symptom profiles
Br J Psychol. 2024 Mar 20. doi: 10.1111/bjop.12701. Online ahead of print.ABSTRACTThe influence of socio-economic status (SES) on child temperament and psychological symptoms was examined using a nationally representative sample in Singapore. Data were available for 2169 children from 1987 families. Caregivers' reports were obtained on children aged 4-6. SES was operationalized as an aggregation of household income per capita, parental education level and housing type. Compared to their counterparts from higher SES families, children from low-SES families tended to exhibit (a) higher negative affectivity but lower effortfu...
Source: British Journal of Psychology - March 20, 2024 Category: Psychiatry & Psychology Authors: Ryan Y Hong Xiao Pan Ding Kelly M Y Chan Wei-Jun Jean Yeung Source Type: research
