Clinician –researchers and custodians of scarce resources: a qualitative study of health professionals’ views on barriers to the involvement of teenagers and young adults in cancer trials
ConclusionsNeither lack of individual equipoise nor experiences of traditional forms of role conflict accounted for the low levels of involvement of TYA with cancer in clinical trials. However, prominent tensions around the management of scarce resources provided an alternative explanation for TYA ’s limited access to cancer trials. The prevailing approach to decision-making about whether and which trials to support was recognised as contributing to inequalities in access and care. Professionals’ choices, however, were made in the context of scarcity, and structured by incentives and sanc tions understood by them as si...
Source: Trials - January 9, 2020 Category: Research Source Type: clinical trials
A systematic review identifying common data items in neonatal trials and assessing their completeness in routinely recorded United Kingdom national neonatal data
ConclusionHigh-impact neonatal clinical trials share common data items. In the United Kingdom, these items can be obtained at a high level of completeness from routinely recorded data held in the NNRD. The feasibility and efficiency using routinely recorded EPR data, such as that held in the NNRD, for clinical trials, rather than collecting these items anew, should be examined.Trial registrationPROSPERO registration numberCRD42016046138. Registered prospectively on 17 August 2016. (Source: Trials)
Source: Trials - December 15, 2019 Category: Research Source Type: clinical trials
A multicentre parallel-group randomised trial assessing multiparametric MRI characterisation and image-guided biopsy of prostate in men suspected of having prostate cancer: MULTIPROS study protocol
DiscussionThe primary objective is to determine whether mpMRI can improve PCa detection and characterisation. The key secondary objective is to determine whether MRI/US fusion-guided biopsy can reduce the number of false-negative biopsies. Ethical approval was obtained from the East of Scotland Research Ethics Committee 1 (14/ES/1070) on 20 November 2014. The results of this study will be used for publication and presentation in national and international journals and at scientific conferences.Trial registrationClinicalTrials.gov,NCT02745496. Retrospectively registered on 20 April 2016. (Source: Trials)
Source: Trials - November 20, 2019 Category: Research Source Type: clinical trials
Effect of the SCOT-HEART 2 Trial on Lifestyle.
Conditions: Coronary Artery Disease; Primary Prevention Intervention: Other: Delivery of CT scan results Sponsors: University of Edinburgh; British Heart Foundation; NHS Lothian Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 7, 2019 Category: Research Source Type: clinical trials
