Evaluating Diuretics in Normal Care (EVIDENCE): protocol of a cluster randomised controlled equivalence trial of prescribing policy to compare the effectiveness of thiazide-type diuretics in hypertension
We describe an approach to rapidly generate externally valid evidence of comparative safety and effectiveness using the example of two widely used diuretics for the management of hypertension.Methods and analysisThe EVIDENCE (Evaluating Diuretics in Normal Care) study has a prospective, cluster-randomised, open-label, blinded end-point design. By randomising prescribing policy in primary care practices, the study compares the safety and effectiveness of commonly used diuretics in treating hypertension. Participating practices are randomised 1:1 to a policy of prescribing either indapamide or bendroflumethiazide when clinic...
Source: Trials - November 17, 2021 Category: Research Source Type: clinical trials
Understanding Persistent Pain Using a Decision Aid Tool in a Scottish Pharmacy Setting.
Condition: Chronic Pain Intervention: Behavioral: Digital Decision Aid Tool Sponsors: University of Aberdeen; Pharmacy Research UK Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 1, 2021 Category: Research Source Type: clinical trials
Social and Cognitive Online Training: the SCOT Project
Conditions: Aging; Cognitive Decline Interventions: Behavioral: SCOT; Behavioral: CON Sponsor: Università degli Studi di Trento Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 26, 2021 Category: Research Source Type: clinical trials
