Life cycle assessment of multi-step rufinamide synthesis - from isolated reactions in batch to continuous microreactor networks
Green Chem., 2015, Advance ArticleDOI: 10.1039/C5GC01932J, PaperDenise Ott, Svetlana Borukhova, Volker HesselRufinamide is an antiepileptic drug to treat Lennox-Gastaut syndrome, in combination with other medications. Herein, several batch and continuous process routes to rufinamide are analysed and optimised regarding their environmental impact, to finally predict a fully continuous, telescoped process route.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Green Chem. latest articles)
Source: RSC - Green Chem. latest articles - October 2, 2015 Category: Chemistry Authors: Denise Ott Source Type: research
Trends in Antiepileptic Drug Prescriptions for Childhood Epilepsy at a Tertiary Children's Hospital in Korea, 2001-2012.
CONCLUSION: This study provided updated information on AED prescription trends for childhood epilepsy. We found a progressive increase in the use of newer AEDs. However, valproic acid, the only prevalent older AED, continued to be widely prescribed. A high rate of polytherapy among the prescriptions overall raises some safety concerns.
PMID: 26400586 [PubMed - as supplied by publisher] (Source: Paediatric Drugs)
Source: Paediatric Drugs - September 23, 2015 Category: Pediatrics Authors: Cho YS, Ah YM, Jung AH, Kim KJ, Lee JY Tags: Paediatr Drugs Source Type: research
Trends in Antiepileptic Drug Prescriptions for Childhood Epilepsy at a Tertiary Children’s Hospital in Korea, 2001–2012
Conclusion
This study provided updated information on AED prescription trends for childhood epilepsy. We found a progressive increase in the use of newer AEDs. However, valproic acid, the only prevalent older AED, continued to be widely prescribed. A high rate of polytherapy among the prescriptions overall raises some safety concerns. (Source: Pediatric Drugs)
Source: Pediatric Drugs - September 23, 2015 Category: Pediatrics Source Type: research
Life Cycle Assessment of Multi-Step Rufinamide Synthesis - from Isolated Reactions in Batch to a Continuous Microreactor Networks
Green Chem., 2015, Accepted ManuscriptDOI: 10.1039/C5GC01932J, PaperDenise Ott, Svetlana Borukhova, Volker HesselRufinamide is an antiepileptic drug to treat Lennox-Gastaut syndrome, in combination with other medications. Rufinamide is one of the best-selling 5-membered ring heterocyclic pharmaceuticals. Its 1,2,3-triazole moiety is made by...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Green Chem. latest articles)
Source: RSC - Green Chem. latest articles - August 28, 2015 Category: Chemistry Authors: Denise Ott Source Type: research
Pharmacokinetics and Tolerability of Rufinamide Following Single and Multiple Oral Doses and Effect of Food on Pharmacokinetics in Healthy Chinese Subjects
Conclusion
Overall, 15 % (6/40) of subjects experienced a mild indisposition with no serious adverse events. On single and multiple dosing, rufinamide exhibited nonlinear pharmacokinetics and was well tolerated in healthy Chinese subjects. (Source: European Journal of Drug Metabolism and Pharmacokinetics)
Source: European Journal of Drug Metabolism and Pharmacokinetics - August 21, 2015 Category: Drugs & Pharmacology Source Type: research
